How is panitumumab used in the treatment of wild-type RAS (both KRAS and NRAS) metastatic colorectal cancer?

Updated: Apr 15, 2020
  • Author: Tomislav Dragovich, MD, PhD; Chief Editor: N Joseph Espat, MD, MS, FACS  more...
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Answer

In June 2017, the FDA extended approval for panitumumab for use in wild-type RAS (both KRAS and NRAS) metastatic colorectal cancer. Approval was based on a retrospective analysis from the PRIME trial and prospective, pre-defined analyses from the phase 3 '0007 study. The '0007 study evaluated the efficacy of panitumumab plus best supportive care (BSC) versus BSC alone in patients with chemorefractory, wild-type KRAS metastatic colorectal cancer. [119] Key secondary endpoint data showed significant improvement in overall survival (OS) of 10 months in BSC with panitumumab compared to 6.9 months with BSC alone.


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