What is Mvasi (bevacizumab-awwb) and how is it used to treat colon cancer?

Updated: Apr 15, 2020
  • Author: Tomislav Dragovich, MD, PhD; Chief Editor: N Joseph Espat, MD, MS, FACS  more...
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Answer

In September 2017, the FDA approved Mvasi (bevacizumab-awwb) as a biosimilar to Avastin (bevacizumab), to be used in combination with fluoropyrimidine-irinotecan– or fluoropyrimidine-oxaliplatin–based chemotherapy for the second-line treatment of patients with metastatic colorectal cancer who have progressed on a first-line bevacizumab-product–containing regimen. The approval was based on evidence from animal study data, human pharmacokinetic and pharmacodynamics data, and clinical immunogenicity data that supported Mvasi as a biosimilar to Avastin. [107]


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