What is the role of tipiracil/trifluridine (Lonsurf) in the treatment of colon cancer?

Updated: Apr 15, 2020
  • Author: Tomislav Dragovich, MD, PhD; Chief Editor: N Joseph Espat, MD, MS, FACS  more...
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In September 2015, the FDA approved tipiracil/trifluridine (Lonsurf) for metastatic colorectal cancer. Efficacy and safety were evaluated in the phase III RECOURSE trial, an international, randomized, double-blind study involving 800 patients with previously treated metastatic colorectal cancer. Patients had received chemotherapy with a fluoropyrimidine, oxaliplatin, irinotecan, bevacizumab, and—for patients with KRAS wild-type tumors—cetuximab or panitumumab. The primary efficacy end point of the study was median overall survival, which was 7.1 months with tipiracil/trifluridine vs 5.3 months with placebo (P < 0.001). The secondary end point was progression-free survival, which was 2 months with tipiracil/trifluridine vs 1.7 months with placebo. [100]

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