What is the significance of deficient mismatch repair (dMMR) in colon cancer?

Updated: Apr 15, 2020
  • Author: Tomislav Dragovich, MD, PhD; Chief Editor: N Joseph Espat, MD, MS, FACS  more...
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Answer

Deficient mismatch repair (dMMR), which is associated with high-frequency microsatellite instability (H-MSI), has been shown to be associated with better clinical outcome for patients with resectable colon cancer, based on a retrospective analysis of several large randomized trials of adjuvant therapy for colon cancer. [69, 70] In addition, patients with dMMR (H-MSI) did not appear to benefit from fluorouracil-based adjuvant therapy. [71]

Testing for dMMR with H-MSI may become useful for prognosis and treatment planning in patients with resectable colon cancer. Some research also emphasizes the role of immune regulation in the development and in the natural course and prognosis of patients with colorectal cancers. [72]


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