What is the significance of KRAS mutations in colon cancer?

Updated: Apr 15, 2020
  • Author: Tomislav Dragovich, MD, PhD; Chief Editor: N Joseph Espat, MD, MS, FACS  more...
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Answer

KRAS mutations, which are present in about 40% of colon adenocarcinomas, affect sensitivity to treatment with biologic agents directed against the epithelial growth factor receptor (EGFR). [68] The US Food and Drug Administration (FDA) has approved a qualitative real-time polymerase chain reaction (PCR) assay, the therascreen KRAS RGQ PCR Kit, for the detection of specific KRAS mutations in the KRAS oncogene.


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