How is Cologuard used to screen for colon cancer?

Updated: Apr 15, 2020
  • Author: Tomislav Dragovich, MD, PhD; Chief Editor: N Joseph Espat, MD, MS, FACS  more...
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In 2014, the FDA approved Cologuard, a colorectal cancer screening tool that detects DNA mutations and hemoglobin in stool samples. A positive result should be followed up with colonoscopy. Cologuard is recommended for screening of adults of either sex, aged 50 years or older, who are at average risk for colorectal cancer. It is not a replacement for diagnostic or surveillance colonoscopy for individuals at high risk, and its approval did not change practice guidelines that recommend screening using colonoscopy, sigmoidoscopy, or fecal occult blood testing. [58]

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