What are independent predictors of worse outcome in patients with colorectal liver metastases?

Updated: Apr 15, 2020
  • Author: Tomislav Dragovich, MD, PhD; Chief Editor: N Joseph Espat, MD, MS, FACS  more...
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Answer

A study by Chua et al found that approximately one in every three patients who undergo resection for colorectal liver metastases become actual 5-year survivors. [33] Of those, approximately half survive 10 years and are cured of colorectal liver metastases. A multivariate analysis of 1001 patients who underwent potentially curative resection of liver metastases identified five factors as independent predictors of worse outcome [34] :

  • Size greater than 5 cm

  • Disease-free interval of less than a year

  • More than one tumor

  • Primary lymph-node positivity

  • Carcinoembryonic antigen (CEA) level greater than 200 ng/mL


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