What is the tumor-node-metastasis (TNM) classification of the American Joint Cancer Committee/Union for International Cancer Control/ (AJCC/UICC) for cholangiocarcinoma (CCC)?

Updated: Dec 28, 2019
  • Author: Peter E Darwin, MD; Chief Editor: N Joseph Espat, MD, MS, FACS  more...
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Answer

Cholangiocarcinoma cancer staging follows the tumor-node-metastasis (TNM) classification of the American Joint Cancer Committee/Union for International Cancer Control/ (AJCC/UICC) and is staged separately for intrahepatic, perihilar, and distal bile duct tumors. [24]

TNM groupings by stage are as follows for each group: [24]

Table. 1 (Open Table in a new window)

Intrahepatic bile duct tumor

Stage

T

N

M

0

Tis

N0

M0

IA

T1a

N0

M0

IB

T1b

N0

M0

II

T2

N0

M0

IIIA

T3

N0

M0

IIIB

T4

N0

M0

 

Any T

N1

M0

IV

Any T

Any N

M1

Table. 2 (Open Table in a new window)

Perihilar bile duct tumor

Stage

T

N

M

0

Tis

N0

M0

I

T1

N0

M0

II

T2a-b

N0

M0

IIIA

T3

N0

M0

IIIB

T4

N0

M0

IIIC

Any T

N1

M0

IVA

T4

N2

M0

IVB

Any T

Any N

M1

Table. 3 (Open Table in a new window)

Distal bile duct tumor

Stage

T

N

M

0

Tis

N0

M0

I

T1

N0

M0

IIA

T1

N1

M0

 

T2

N0

M0

IIB

T2

N1

M0

 

T3

N0

M0

 

T3

N1

M0

IIIA

T1-3

N2

M0

IIIB

T4

N0-2

M0

IV

Any T

Any N

M1

 

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