How is cardiac sarcoma treated?

Updated: Jan 17, 2019
  • Author: John H Raaf, MD, PhD; Chief Editor: Eric H Yang, MD  more...
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Answer

For treatment of cardiac sarcoma, complete surgical excision remains the therapeutic mainstay, followed by radiotherapy with or without sequential chemotherapy. Chemotherapy regimens containing anthracyclines, ifosfamide or taxanes have been reported. [15]

In one case report, preoperative chemotherapy reduced the size of an unresectable undifferentiated cardiac sarcoma, so that residual tumor could then be completely resected. [16]  In a case series of 44 patients with primary right-sided sarcomas, survival was doubled (20 months vs 9.5 months) with the addition of neoadjuvant chemotherapy. [17]

In a retrospective chart review, patients who received multimodality treatment (any combination of surgery, radiation therapy, and chemotherapy) had an estimated median survival of 36.5 months compared with 14.1 months for patients treated with surgery, radiation therapy, or chemotherapy only (P=0.05). [9]


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