Which medications in the drug class Antineoplastics, Hedgehog Pathway Inhibitor are used in the treatment of Basal Cell Carcinoma?

Updated: Mar 02, 2020
  • Author: Robert S Bader, MD; Chief Editor: William D James, MD  more...
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Answer

Antineoplastics, Hedgehog Pathway Inhibitor

The Hedgehog signaling pathway is important in embryogenesis, but in adults, it is mostly inactive. Signaling is relayed by key proteins including Smoothened homologue (SMO). Hedgehog ligand-expressing cancerous epithelial cells that are activated by the hedgehog signaling pathway may cause growth-promotion.

Vismodegib (Erivedge)

Vismodegib is a Hedgehog (Hh) pathway inhibitor. Vismodegib binds to and inhibits SMO, a transmembrane protein involved in Hedgehog signal transduction. This agent is indicated for treatment of adults with metastatic basal cell carcinoma or with locally advanced basal cell carcinoma that has recurred following surgery, or those who are not candidates for surgery or radiation.

Sonidegib (Odomzo)

Sonidegib binds to and inhibits SMO, a transmembrane protein involved in Hedgehog signal transduction. Indicated for adults with locally advanced basal cell carcinoma that has recurred following surgery or radiation therapy, or those who are not candidates for surgery or radiation therapy.


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