What are types of high-risk basal cell carcinoma (BCC)?

Updated: Mar 02, 2020
  • Author: Robert S Bader, MD; Chief Editor: William D James, MD  more...
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Answer

High-risk BCCs include the following:

  • Recurrent or incompletely excised BCC

  • Primary BCC with clinically indistinct borders

  • Lesions in high-risk (the H, or mask) areas, mainly the embryonic fusion planes (eg, eyelids, nose, ear, nasolabial folds, upper lip, vermillion border, columella, periorbital region, temples, preauricular and postauricular areas, and scalp)

  • Lesions that develop in cosmetically and functionally important areas (eg, face, genitals, anal and perianal regions, hands and feet, and the nail unit areas)

  • Tumors with aggressive clinical behavior (ie, growing rapidly or >2 cm)

  • Tumors with aggressive histologic subtype, including sclerosing (morpheaform), basosquamous (metatypical or keratinizing), perineural, periappendageal, or perivascular invasion, infiltrating, adenoidal, or multicentric

  • Tumors that develop in sites with previous radiation therapy

  • Tumors that develop in immunosuppressed patients


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