How is cutaneous angiosarcoma (AS) treated?

Updated: Dec 02, 2020
  • Author: Maria Belén Carsi, MD, PhD, FRCS; Chief Editor: Edwin Choy, MD, PhD  more...
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Answer

The best outcomes are reported with surgery followed by radiotherapy. The role of chemotherapy in cutaneous angiosarcoma has not yet been established, although for patients with metastasis or tumors deemed unresectable, doxorubicin (intraarterial or systemic) is indicated. [33]

Paclitaxel as a single agent has shown substantial activity against cutaneous angiosarcoma, even in patients previously treated with chemotherapy or radiation therapy. [34]  Solid evidence supports first-line use of paclitaxel in advanced cutaneous angiosarcoma. Options for second-line treatment include pazopanib, eribulin, and trabectedin. [35]


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