What is the role of tranexamic acid in the treatment of postpartum hemorrhage (PPH)?

Updated: Jun 27, 2018
  • Author: John R Smith, MD, FACOG, FRCSC; Chief Editor: Ronald M Ramus, MD  more...
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A randomized double-blind, placebo-controlled trial by the WOMAN Trial Collaborators reported that tranexamic acid significantly reduced death due to bleeding in women with postpartum hemorrhage when compared to the placebo group (155 [1.5%] of 10,036 patients vs 191 [1.9%] of 9985 patients in the placebo group). The study also found that the effects of tranexamic acid was greater when given within 3 hours of giving birth (89 [1·2%] vs 127 [1·7%] in the placebo group. Adverse events did not differ significantly in the two groups. [32]

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