Which medications in the drug class Gonadotropin Releasing Hormone Antagonists are used in the treatment of Androgen Excess?

Updated: Mar 14, 2018
  • Author: Mohamed Yahya Abdel-Rahman, MD, MSc; Chief Editor: Richard Scott Lucidi, MD, FACOG  more...
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Answer

Gonadotropin Releasing Hormone Antagonists

These agents, which suppress pituitary LH and FSH secretion, suppress ovarian hormone secretion to a greater degree than COCs. Examples of GnRH agonists in the United States include Lupron, Synarel, and Zoladex. The endometriosis doses are the ones used for hirsutism. Significant osteoporosis may occur if treatment lasts longer than 6 months; in these cases, estrogen add back with HRT or COC pills should be given.

Leuprolide acetate (Lupron, Lupron Depot)

Suppresses ovarian and testicular steroidogenesis by decreasing LH and FSH levels.

Nafarelin acetate (Synarel)

Suppresses secretion of LH and FSH, which in turn reduces ovarian and testicular steroid production. Available as nasal solution (2 mg/mL).

Goserelin (Zoladex)

Suppresses ovarian and testicular steroidogenesis by decreasing LH and FSH levels.


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