When is 24-hour urine free cortisol measurement indicated in the evaluation of androgen excess?

Updated: Mar 14, 2018
  • Author: Mohamed Yahya Abdel-Rahman, MD, MSc; Chief Editor: Richard Scott Lucidi, MD, FACOG  more...
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Answer

Women with clinical evidence of Cushing syndrome (moon face, buffalo hump, obesity, hypertension, and dyslipidemia) should be evaluated by measuring 24-hour urine free cortisol. This test has a sensitivity >95% and specificity of 98% for diagnosing Cushing syndrome and is more specific than the dexamethasone suppression test. [78, 55]


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