What is the role of 17-hydroxyprogesterone measurement in the evaluation of androgen excess?

Updated: Mar 14, 2018
  • Author: Mohamed Yahya Abdel-Rahman, MD, MSc; Chief Editor: Richard Scott Lucidi, MD, FACOG  more...
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Answer

Measuring serum levels of 17-hydroxyprogesterone is a screening test for nonclassic congenital adrenal hyperplasia. [69] Enzyme defects (most commonly 21-hydroxylase) result in increased levels of 17-hydroxyprogesterone. Women with levels > 200 ng/dL (6.05 nmol/L) should be further evaluated with a corticotrophin stimulation test.


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