What is the role of hyperandrogenism, insulin resistance, and acanthosis nigricans (HAIR-AN) syndrome in the etiology of androgen excess?

Updated: Apr 07, 2020
  • Author: Mohamed Yahya Abdel-Rahman, MD, MSc; Chief Editor: Richard Scott Lucidi, MD, FACOG  more...
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Answer

HAIR-AN syndrome is a subset of women with PCOS who present with hyperandrogenism, insulin resistance, acanthosis nigricans, and obesity in the absence of insulin receptor defect. [50] This syndrome is found in 1-3% of hyperandrogenic women. [51] HAIR-AN syndrome is characterized by high levels of post-glucose challenge insulin levels that may reach 300-500 µU/mL. [52]


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