What is the mortality and morbidity of androgen excess?

Updated: Mar 14, 2018
  • Author: Mohamed Yahya Abdel-Rahman, MD, MSc; Chief Editor: Richard Scott Lucidi, MD, FACOG  more...
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Answer

Androgen excess per se does not cause mortality or morbidity, but it is associated with insulin resistance, dyslipidemia, hypertension, and vascular diseases; [5] therefore, it is a forerunner of cardiovascular disease.

  • In premenopausal African-American women, relative androgen excess is associated with insulin resistance and increased risk for development of type 2 diabetes. [25]

  • Impaired glucose tolerance and type 2 diabetes affect about 40% of women with PCOS.

  • The presence of PCOS is an independent cardiovascular risk factor. Women who have anovulatory PCOS have greater cardiovascular risk compared with women who have ovulatory PCOS and idiopathic hyperandrogenism.

  • Androgen-secreting tumors are rare and about 30% of them are malignant.


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