Which factors increase or decrease sex hormone binding globulin (SHBG) levels?

Updated: Apr 07, 2020
  • Author: Mohamed Yahya Abdel-Rahman, MD, MSc; Chief Editor: Richard Scott Lucidi, MD, FACOG  more...
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SHGB levels are increased by the following:

  • Estrogens

  • Thyroid hormone

  • Pregnancy

  • Estrogen-containing preparations

SHGB levels are decreased by the following:

  • Androgens

  • Synthetic progestins (norethindrone, norgestrel, desogestrel, norgestimate)

  • Glucocorticoids

  • Growth hormone

  • Insulin

  • Obesity

  • Acromegaly

  • Hypothyroidism

  • Hyperinsulinemia

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