Which medications in the drug class Antigonadotropic Agents are used in the treatment of Endometriosis?

Updated: May 10, 2021
  • Author: G Willy Davila, MD; Chief Editor: Michel E Rivlin, MD  more...
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Answer

Antigonadotropic Agents

Antigonadotropic agents work to suppress both the hypothalamic-ovarian axis and endometriosis at a local level and act by inhibiting the midcycle follicle-stimulating hormone (FSH) and luteinizing hormone (LH) surge and preventing steroidogenesis in the corpus luteum. These are the most extensively studied agents for endometriosis. Danazol has been shown to be as effective as any of the newer agents, but it has a higher incidence of adverse effects.

Danazol

Danazol is a synthetic steroid analogue with strong antigonadotropic activity (inhibits luteinizing hormone [LH] and follicle-stimulating hormone [FSH]) and weak androgenic action.

However, although efficacious, androgens have fallen out of favor because of their unpleasant adverse effects, and because newer medications work as well or better. These drugs may represent a less expensive alternative, or better choice, for certain patients and remain part of the armamentarium. Danazol requires at least 3-6 months to determine its effectiveness.


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