What is the role of danazol for the treatment of endometriosis?

Updated: May 10, 2021
  • Author: G Willy Davila, MD; Chief Editor: Michel E Rivlin, MD  more...
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Answer

Danazol acts by inhibiting the midcycle follicle-stimulating hormone (FSH) and luteinizing hormone (LH) surges and preventing steroidogenesis in the corpus luteum. It is the most extensively studied agent for endometriosis.

Danazol has been shown to be as effective as any of the newer agents, but with a higher incidence of adverse effects. Its androgenic manifestations include oily skin, acne, weight gain, deepening of the voice, and facial hirsutism. Hypoestrogenic features due to danazol include emotional lability, hot flashes, vaginal dryness, and reversible breast atrophy.

The recommended dose is 600-800 mg/d. However, smaller doses have been used with success. [88, 89] In a small study of 21 patients, vaginal danazol (200 mg/d) was successful in relieving endometriosis-associated pain. [90]


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