What is the role of hormonal therapy in the treatment of endometriosis?

Updated: May 10, 2021
  • Author: G Willy Davila, MD; Chief Editor: Michel E Rivlin, MD  more...
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Answer

The dependence of endometriosis on the woman's cyclic production of menstrual cycle hormones provides the basis for medical therapy. Thus, combination oral contraceptive pills (COCPs), danazol, progestational agents, and gonadotropin-releasing hormone (GnRH) analogues form the mainstay of medical therapy. All these treatments have similar clinical efficacy in terms of reduction in pain-related symptoms and duration of relief. See Medications.

Nonsteroidal anti-inflammatory agents (NSAIDS) have not been shown to have any benefit in placebo-controlled trials. [67] In a systematic review, aromatase inhibitors were shown to have promising results for pain relief when combined with either progestins, COCPs , or GnRH analogues. [68] However, the authors concluded that the strength of this inference was limited due to lack of sizeable trials. [68]


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