What is the sensitivity and specificity of autoantibodies against Thomsen-Friedenreich (T) antigen (Gal beta1-3GalNAc) in the diagnosis of endometriosis?

Updated: May 10, 2021
  • Author: G Willy Davila, MD; Chief Editor: Michel E Rivlin, MD  more...
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Answer

A diagnostic test based on the detection of autoantibodies against Thomsen-Friedenreich (T) antigen (Gal beta1-3GalNAc) bearing proteins appears promising. The sensitivity and specificity of the test are 80%. This test may prove useful in the outpatient setting. [51]

Another office test is the marker CCR1. The expression of the blood-borne marker CCR1 mRNA in peripheral blood leukocytes is significantly higher in women with endometriosis compared with unaffected women. [52]


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