What is the role of a serum cancer antigen 125 (CA-125) test in the workup of endometriosis?

Updated: May 10, 2021
  • Author: G Willy Davila, MD; Chief Editor: Michel E Rivlin, MD  more...
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Answer

With a serum cancer antigen 125 (CA-125) test, serial measurements have a low sensitivity in detecting endometriosis, [49] although levels may be elevated in advanced cases, but the results are useful as prognosticators of treatment outcome. [50] However, normal posttreatment values do not mean that endometriosis is absent. Thus, the test lacks adequate sensitivity or specificity to be of clinical value.


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