What are the ACOG recommendations for use of corticosteroid in the management of premature rupture of membranes (PROM)?

Updated: Oct 05, 2018
  • Author: Allahyar Jazayeri, MD, PhD, FACOG, DACOG, FSMFM; Chief Editor: Carl V Smith, MD  more...
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Current ACOG recommendations [24, 2]

  • A single course of corticosteroids is recommended for pregnant women 24-34 weeks' gestation who are at risk of preterm delivery within 7 days and as early as 23 weeks if delivery is imminent.

  • A single rescue course of antenatal corticosteroids may be considered if the antecedent treatment was given more than 2 weeks prior, the gestational age is less than 32 6/7 weeks, and the woman is judged by the clinician to be likely to give birth within the next week. However, regularly scheduled repeat courses or more than 2 courses are not recommended.

  • Further research regarding the risks and benefits, optimal dose, and timing of a single rescue course of steroid treatment is needed.

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