What are the risks and benefits of antibiotic use for premature preterm rupture of membranes (PPROM)?

Updated: Oct 05, 2018
  • Author: Allahyar Jazayeri, MD, PhD, FACOG, DACOG, FSMFM; Chief Editor: Carl V Smith, MD  more...
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The ORACLE trial used erythromycin alone, amoxicillin clavulanic acid alone, or amoxicillin clavulanic acid in combination with erythromycin. Their results were different in that no significant difference was noted in latency to delivery and neonatal morbidity was not decreased as defined in their primary outcome (death, chronic lung disease, and major cerebral abnormality on ultrasonography). Decreased need for supplemental oxygen and positive blood culture results were apparent. When amoxicillin clavulanic acid was used either alone or in combination with erythromycin, an increased risk of necrotizing enterocolitis (1.9% vs 0.5%, p =0.001) was present. [19]

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