What are the risks of premature preterm rupture of membranes (PPROM) in the second trimester?

Updated: Oct 05, 2018
  • Author: Allahyar Jazayeri, MD, PhD, FACOG, DACOG, FSMFM; Chief Editor: Carl V Smith, MD  more...
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Premature preterm rupture of membranes (PPROM) prior to fetal viability is a unique and relatively rare problem that is often difficult to manage. It occurs in less than 0.4% of all pregnancies. [15] The major maternal risk is infection, namely chorioamnionitis, which occurs in about 35%; abruption, which occurs in 19%; and sepsis, which is rare and occurs in less than 1%. [15] The major morbidity in the fetus with midtrimester ROM is lethal pulmonary hypoplasia from prolonged, severe, early oligohydramnios, which occurs in about 20% of cases. Other morbidities such as RDS (66%), sepsis (19%), grade III-IV IVH (5%), and contractures (3%) also occur with high frequency, resulting in intact survival rates of more than 67%. Fetal death is common and occurs in more than 30%. [15]

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