How can the likelihood of premature preterm rupture of membranes (PPROM) be predicted?

Updated: Oct 05, 2018
  • Author: Allahyar Jazayeri, MD, PhD, FACOG, DACOG, FSMFM; Chief Editor: Carl V Smith, MD  more...
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A study by Ekin et al suggested that mean platelet volume (MPV) in the first trimester of pregnancy can be used to predict the likelihood of PPROM. In a retrospective record review of 318 women with PPROM and 384 controls, the investigators found that, comparing values between the 7th and 14th weeks of gestation, the MPVs were significantly lower and the platelet counts significantly higher in patients who had experienced PPROM than in pregnant women who had not. Using cutoff values of less than or equal to 8.6 fL for MPV and greater than or equal to 216 x 103/µL for platelet count, the study found that these measurements had a sensitivity and specificity for predicting PPROM of 58% and 65%, respectively, and 62% and 44%, respectively. Ekin and colleagues concluded that MPV is more efficient than platelet count for predicting PPROM. [13]

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