What is the role of placental alpha-microglobulin-1 levels in the diagnosis of premature rupture of membranes (PROM)?

Updated: Oct 05, 2018
  • Author: Allahyar Jazayeri, MD, PhD, FACOG, DACOG, FSMFM; Chief Editor: Carl V Smith, MD  more...
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Ng et al reported placental alpha-microglobulin-1 levels have a 95.7% sensitivity, 100% specificity, 100% positive predictive value, and 75% negative predictive value. [6]  In select cases when the diagnoses or ROM is not clear, placental alpha-microglobulin-1 should be used to provide additional information for appropriate management. 

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