What causes midtrimester pregnancy loss?

Updated: May 04, 2021
  • Author: Michael G Ross, MD, MPH; Chief Editor: Carl V Smith, MD  more...
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Midtrimester loss has many etiologies, including infection (eg, syphilis), antiphospholipid syndrome, diabetes, substance abuse, genetic disorders, congenital müllerian abnormalities, cervical trauma, and cervical incompetence. Unfortunately, many midtrimester losses remain unexplained. A complete workup (see History of midtrimester loss) may be of value in selected patients following a midtrimester loss.

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