How is malignant struma ovarii characterized?

Updated: Mar 08, 2019
  • Author: Lisa Rubinsak, MD; Chief Editor: Michel E Rivlin, MD  more...
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Answer

Malignant struma ovarii is divided into 3 different categories by histology.

  • Papillary type is the most common and identified by “ground glass” or overlapping nuclei.
  • The follicular variant of papillary carcinoma shares the same nuclear characteristics as the papillary type, but has a follicular architecture.
  • Follicular carcinoma in struma ovarii is identified by vascular and/or capsular invasion. [11]

Strumal carcinoid has both struma ovarii and carcinoid tumor, with the carcinoid component considered by many to be a malignant transformation. Carcinoid tumor cells often have higher proliferative rate and invade into the struma. Histologically, they can grow in trabecular or insular pattern, some with glands or cysts containing goblet cells. They typically exhibit no aggressive clinical behavior and surgical excision is often curative. [11]


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