What is the clinical presentation characteristic of hydatidiform mole?

Updated: Feb 16, 2018
  • Author: Lisa E Moore, MD, MS, FACOG, RDMS; Chief Editor: Warner K Huh, MD  more...
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In a retrospective study (1994-2013) at a Brazilian trophoblastic disease center, investigators evaluated the clinical presentations and incidence of postmolar gestational trophoblastic neoplasia (GTN) among 355 women with complete mole (n =186) or partial mole (n = 169), with the following findings [33] :

  • Risk of vaginal bleeding, biochemical hyperthyroidism, anemia, uterine size larger than dates, and hyperemesis: Reduced risk in women with partial mole
  • Preevacuation serum hCG levels: Lower in women with partial mole
  • Median gestational age at evacuation: complete mole, 9 weeks; partial mole, 12 weeks
  • Development of GTN:  women with complete mole, 17.7%; women with partial mole, 4.1%

Those with complete mole were diagnosed more commonly before evacuation than women with partial mole because they presented more often with signs/symptoms of molar disease. [33]

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