Which patients are most likely to develop hydatidiform moles?

Updated: Feb 16, 2018
  • Author: Lisa E Moore, MD, FACOG; Chief Editor: Warner K Huh, MD  more...
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Answer

Differences in the frequency of hydatidiform moles between ethnic groups have been reported internationally. [13, 15] In the United States, a cross-sectional study of 140 complete moles and 115 partial moles found that Asian women were more than twice as likely as white women to have a complete mole but were less likely to have a partial mole. Hispanic women were 60% less likely to have a complete mole. White women had the greatest risk of partial molar pregnancy. African-American and Hispanic women had similar risk of complete mole but when adjusted for age, African-American women had a marginally decreased risk. [16]

Hydatidiform mole is a disease of pregnancy and therefore a disease of women.

Hydatidiform mole is more common at the extremes of reproductive age. Women in their early teenage or perimenopausal years are most at risk. [1, 13, 15, 17, 18] Women older than 35 years have a 2-fold increase in risk. Women older than 40 years experience a 5- to 10-fold increase in risk compared to younger women. Parity does not affect the risk.


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