What are complete biparental hydatidiform mole?

Updated: Feb 16, 2018
  • Author: Lisa E Moore, MD, MS, FACOG, RDMS; Chief Editor: Warner K Huh, MD  more...
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The biparental complete mole is rare. Maternal and paternal genes are present but failure of maternal imprinting causes only the paternal genome to be expressed. [5]

A recurrent form of biparental mole, which is familial and appears to be inherited as an autosomal recessive trait, has been described. Al-Hussaini describes a series of 5 women with as many as 9 consecutive molar pregnancies. [6, 7]

Mutations in NLRP7 at 19q13.4 have been identified as causative in recurrent molar pregnancies. [8, 9, 10]

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