How are eclamptic seizures unresponsive to magnesium sulfate managed?

Updated: Apr 18, 2019
  • Author: Michael G Ross, MD, MPH; Chief Editor: Ronald M Ramus, MD  more...
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About 10% of women with eclampsia will have an additional seizure after receiving magnesium sulfate. Another 2 g bolus of magnesium may be given in these cases. For the rare patient who continues to have seizure activity while receiving adequate magnesium therapy, seizures may be treated with sodium amobarbital, 250 mg IV over 3-5 minutes. [22] Alternatively, lorazepam or diazepam may be administered (as described above) for status epilepticus. However, these drugs can be associated with prolonged neonatal neurologic depression.

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