What is the role of antiangiogenic factors in the pathophysiology of eclampsia?

Updated: Apr 18, 2019
  • Author: Michael G Ross, MD, MPH; Chief Editor: Ronald M Ramus, MD  more...
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Answer

Answer

In addition, it is believed that antiangiogenic factors, such as placental protein fms-like tyrosine kinase 1 (sFlt-1) and activin A, antagonize vascular endothelial growth factor (VEGF). [9] Elevated levels of these proteins cause a reduction of VEGF and induce systemic and local endothelial cell dysfunction. [1]


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