Which pharmacologic drugs are the most common treatment for dysmenorrhea?

Updated: Sep 23, 2019
  • Author: Karim Anton Calis, PharmD, MPH, FASHP, FCCP; Chief Editor: Michel E Rivlin, MD  more...
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Answer

NSAIDs are the most common treatment for both primary and secondary dysmenorrhea. They decrease menstrual pain by decreasing intrauterine pressure and lowering prostaglandin F2α (PGF2α) levels in menstrual fluid. [56, 57, 58] NSAIDs that inhibit type I prostaglandin synthetase and suppress production of cyclic endoperoxides (eg, fenamates, cyclooxygenase [COX]-2–selective agents, propionic acids, and indole acetic acids) alleviate symptoms by decreasing endometrial and menstrual fluid prostaglandin concentrations.


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