What is the role of leukotrienes in the pathogenesis of primary dysmenorrhea?

Updated: Oct 22, 2018
  • Author: Karim Anton Calis, PharmD, MPH, FASHP, FCCP; Chief Editor: Michel E Rivlin, MD  more...
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Answer

Leukotrienes have been postulated to heighten the sensitivity of pain fibers in the uterus. Substantial amounts of leukotrienes have been demonstrated in the endometria of women with primary dysmenorrhea that does not respond to treatment with prostaglandin antagonists. [11, 19, 20, 21, 22]


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