What are the recommendations for treatment of advanced cervical cancer?

Updated: Feb 12, 2019
  • Author: Cecelia H Boardman, MD; Chief Editor: Warner K Huh, MD  more...
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Answer

The NCCN acknowledges that traditionally, advanced disease included stages IIB-IVA; however, many oncologists now also include patients with IB2 and IIA2 in the advanced disease category. The NCCN advises that concomitant chemoradiation and brachytherapy is the standard of care. Radiation therapy is given in four to six cycles of 1.8-2 Gy, with one of the following cisplatin-based chemotherapy regimens [8] :

  • Cisplatin 40 mg/m2 IV once weekly (not to exceed 70 mg/wk) or

  • Cisplatin 50-75 mg/m2 IV on day 1 plus  5-fluorouracil (5-FU) 1000 mg/m2 continuous IV infusion on days 2-5 and days 30-33 (total dose 4000 mg/m2 each course) or

  • Cisplatin 50-75 mg/m2 IV on day 1 plus  5-FU 1000 mg/m2 continuous IV infusion over 24 h on days 1-4 (total dose 4000 mg/m2 each cycle) every 3 wk for a total of three to four cycles

The ESMO guidelines provide similar recommendations. [108]


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