What algorithms are provided by ASCCP for management of abnormal cervical cancer screening results?

Updated: Feb 12, 2019
  • Author: Cecelia H Boardman, MD; Chief Editor: Warner K Huh, MD  more...
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ASCCP also provided management algorithms for the following scenarios [58] :

  • Women with unsatisfactory cytology
  • Women with negative cytology but endocervical/transformation zone absent or insufficient
  • Pregnant women with LSIL
  • Women with atypical squamous cells; cannot exclude ASC-H
  • Women diagnosed with adenocarcinoma in situ (AIS) during a diagnostic excisional procedure

The ASCCP consensus guidelines, which are also endorsed by the National Comprehensive Cancer Network (NCCN), include the following major recommendations [58] :

  • If either (but not both) Pap smear or HPV testing yields positive results, co-testing is integrated into follow-up care; colposcopy, HPV DNA typing, or both may be indicated
  • Return to "routine" screening in women treated for cervical cancer
  • Colposcopy may be required for women with positive HPV results or with repeated unsatisfactory cytological findings that are missing endocervical or transformation zone component

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