What is the efficacy of vaccines for human papillomavirus (HPV) infection?

Updated: Feb 12, 2019
  • Author: Cecelia H Boardman, MD; Chief Editor: Warner K Huh, MD  more...
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Answer

Evidence suggests that HPV vaccines prevent HPV infection. [5] PATRICIA (PApilloma TRIal against Cancer In young Adults) found HPV 16/18 vaccine to be efficacious against cervical intraepithelial neoplasia (CIN) grade 2 or 3 and adenocarcinoma in situ, irrespective of the HPV type in the lesion. [96] Cross-protective efficacy was demonstrated against 4 oncogenic HPV types not included in the vaccine. [97] Use of an HPV 6/11/16/18 vaccine reduced the risk of any high-grade cervical lesions by 19.0% overall, irrespective of causal HPV type. [95]


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