What are the possible interpretations of histologic findings in cervical cancer?

Updated: Feb 12, 2019
  • Author: Cecelia H Boardman, MD; Chief Editor: Warner K Huh, MD  more...
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Possible interpretations or results are as follows:

  • Negative for intraepithelial lesion or malignancy

  • Observed organisms (eg, Trichomonas, Candida, bacteria) and cellular changes consistent with herpes simplex virus are reported

  • Reporting other nonneoplastic findings (ie, inflammation and atrophy) is optional

  • Epithelial cell abnormalities

  • Squamous cell

  • Atypical squamous cells (ASC)


  • ASC where a high-grade squamous intraepithelial lesion (HSIL) cannot be excluded (ASC-H)

  • Low-grade squamous intraepithelial lesion (LSIL)

  • Encompassing HPV, mild dysplasia, and CIN 1 (see the first image below)

  • HSIL

  • Encompassing moderate and severe dysplasia, carcinoma in situ, CIN 2, and CIN 3 (see the second image below)

  • Squamous cell carcinoma (see the third image below)

  • Glandular cell

  • Atypical glandular cells (AGC) (specify endocervical, endometrial, or not otherwise specified)

  • AGC favoring neoplastic (specify endocervical or not otherwise specified)

  • Endocervical adenocarcinoma in situ (AIS)

  • Adenocarcinoma

  • Other (list not comprehensive)

  • Endometrial cells in a woman aged 40 years or older

    Cervical intraepithelial neoplasia grade I. Cervical intraepithelial neoplasia grade I.
    Cervical intraepithelial neoplasia grade III. Cervical intraepithelial neoplasia grade III.
    Squamous cell cervical carcinoma. Squamous cell cervical carcinoma.

Automated review and ancillary testing are included as appropriate. Educational notes and suggestions are optional.

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