What is the role of human leukocyte antigen (HLA) genes in the pathophysiology of cervical cancer?

Updated: Feb 12, 2019
  • Author: Cecelia H Boardman, MD; Chief Editor: Warner K Huh, MD  more...
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Answer

Human leukocyte antigen (HLA) genes are involved in various ways. Some HLA gene anomalies are associated with an increased risk of HPV infection progressing to cancer, [22, 23] others with a protective effect. [24, 25] The chemokine receptor-2 (CCR2) gene on chromosome 3p21 [26, 27] and the Fas gene on chromosome 10q24.1 [23, 28] may also influence genetic susceptibility to cervical cancer, perhaps by disrupting the immune response to HPV. The CASP8 gene (also known as FLICE or MCH5) has a polymorphism in the promoter region that has been associated with a decreased risk of cervical cancer. [29]


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