What is the role of prolactin measurements in the evaluation of amenorrhea?

Updated: Oct 14, 2019
  • Author: Kristi A Tough DeSapri, MD; Chief Editor: Richard Scott Lucidi, MD, FACOG  more...
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Prolactin levels in excess of 200 ng/mL are not observed except in the case of prolactin-secreting pituitary adenoma (prolactinoma) or anti depressants such as Risperidone {ref 87}. In general, the serum prolactin level correlates with the size of the tumor. For more details, see Hyperprolactinemia.

Psychotropic drugs, hypothyroidism, stress, and meals can also raise prolactin levels. Repeat prolactin levels in a fasting state without recent nipple stimulation or sexual intercourse to verify a persistent elevation. Persistent elevations require further evaluation if the cause is not readily apparent.

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