What is the role of cocaine use in the etiology of abruptio placentae?

Updated: Nov 30, 2018
  • Author: Shad H Deering, MD; Chief Editor: Carl V Smith, MD  more...
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Answer

The hypertension and increased levels of catecholamines caused by cocaine abuse are thought to be responsible for a vasospasm in the uterine blood vessels that causes placental separation and abruption. However, this hypothesis has not been definitively proven.

The rate of abruption in patients who abuse cocaine has been reported to be approximately 13-35% and may be dose-dependent. [10]


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