What is the role of vitamin D in the treatment of COVID-19?

Updated: Jan 12, 2021
  • Author: Setu K Patolia, MD, MPH; Chief Editor: Zab Mosenifar, MD, FACP, FCCP  more...
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Answer

Answer

Vitamin D receptor signaling has shown to play a role in decreasing the storm of cytokines and chemokines, modulating neutrophil activity and the renin angiotensin system, and maintaining the pulmonary epithelial barrier. [56] In animal studies, vitamin D receptor knockout mice experienced more severe lung injury than wild mice. [56] There are currently several ongoing observational and interventional studies evaluating the use of vitamin D for the prevention and/or management of ARDS in the setting of COVID-19.


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