What is the role of lopinavir-ritonavir in the treatment of COVID-19?

Updated: Jan 12, 2021
  • Author: Setu K Patolia, MD, MPH; Chief Editor: Zab Mosenifar, MD, FACP, FCCP  more...
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Answer

Answer

Lopinavir, an antiviral used in the treatment of HIV infection, was initially shown to have in vitro activity against SARS in 2003. Ritonavir is added to lopinavir to increase the plasma half-life through the inhibition of cytochrome P-450. Despite initial enthusiasm, a randomized controlled trial failed to show a mortality benefit. [38] For hospitalized patients with COVID-19, IDSA guidelines recommend against the use of lopinavir-ritonavir. [35]


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