What is the role of lopinavir-ritonavir in the treatment of COVID-19?

Updated: Jan 12, 2021
  • Author: Setu K Patolia, MD, MPH; Chief Editor: Zab Mosenifar, MD, FACP, FCCP  more...
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Lopinavir, an antiviral used in the treatment of HIV infection, was initially shown to have in vitro activity against SARS in 2003. Ritonavir is added to lopinavir to increase the plasma half-life through the inhibition of cytochrome P-450. Despite initial enthusiasm, a randomized controlled trial failed to show a mortality benefit. [38] For hospitalized patients with COVID-19, IDSA guidelines recommend against the use of lopinavir-ritonavir. [35]

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