Which medications in the drug class Corticosteroids are used in the treatment of Coronavirus Disease 2019 (COVID-19)?

Updated: Jun 25, 2021
  • Author: David J Cennimo, MD, FAAP, FACP, FIDSA, AAHIVS; Chief Editor: Michael Stuart Bronze, MD  more...
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Answer

Corticosteroids

NIH guidelines for COVID-19 recommends use of dexamethasone to reduce mortality in hospitalized patients who are mechanically ventilated or those requiring supplemental oxygen without mechanical ventilation. [366]  These recommendations are based on results of the RECOVERY trial. [23]  

If dexamethasone is unavailable, use alternant glucocorticoids (eg, prednisone, methylprednisolone, or hydrocortisone). [366]  

Dexamethasone

Decreases inflammation by suppressing migration of polymorphonuclear leukocytes (PMNs) and reducing capillary permeability; stabilizes cell and lysosomal membranes.

Prednisone (Deltasone)

Consider use if dexamethasone is unavailable. Available as oral formulation. 

Methylprednisolone (A-Methapred, DepoMedrol, Medrol)

Consider use if dexamethasone is unavailable. Available as IV formulation.

Hydrocortisone

Consider use if dexamethasone is unavailable. Available as oral or IV formulations.


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