Which medications in the drug class Antiviral Agents are used in the treatment of Coronavirus Disease 2019 (COVID-19)?

Answer

Antiviral Agents

Remdesivir is the first drug approved by the FDA for COVID-19.

Remdesivir (Veklury)

Adenosine nucleotide prodrug that distributes into cells, where it is metabolized to form the pharmacologically active nucleoside triphosphate metabolite. Inhibits SARS-CoV-2 RNA-dependent RNA polymerase (RdRp), which is essential for viral replication. It is indicated. It is indicated for treatment of COVID-19 disease in hospitalized adults and children aged 12 years and older who weigh at least 40 kg. An EUA is approved for pediatric patients weighing 3.5 kg to less than 40 kg or children younger than 12 years who weigh at least 3.5 kg.

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CDC. 2019 Novel Coronavirus, Wuhan, China. CDC. Available at https://www.cdc.gov/coronavirus/2019-ncov/about/index.html. January 26, 2020; Accessed: January 27, 2020.
Gallegos A. WHO Declares Public Health Emergency for Novel Coronavirus. Medscape Medical News. Available at https://www.medscape.com/viewarticle/924596. January 30, 2020; Accessed: January 31, 2020.
Ramzy A, McNeil DG. W.H.O. Declares Global Emergency as Wuhan Coronavirus Spreads. The New York Times. Available at https://nyti.ms/2RER70M. January 30, 2020; Accessed: January 30, 2020.
The New York Times. Coronavirus Live Updates: W.H.O. Declares Pandemic as Number of Infected Countries Grows. The New York Times. Available at https://www.nytimes.com/2020/03/11/world/coronavirus-news.html#link-682e5b06. March 11, 2020; Accessed: March 11, 2020.
Coronavirus Updates: The Illness Now Has a Name: COVID-19. The New York Times. Available at https://www.nytimes.com/2020/02/11/world/asia/coronavirus-china.html. February 11, 2020; Accessed: February 11, 2020.
WHO Director-General's remarks at the media briefing on 2019-nCoV on 11 February 2020. Available at https://www.who.int/dg/speeches/detail/who-director-general-s-remarks-at-the-media-briefing-on-2019-ncov-on-11-february-2020. February 11, 2020; Accessed: February 13, 2020.
Gorbalenya AE. Severe acute respiratory syndrome-related coronavirus – The species and its viruses, a statement of the Coronavirus Study Group. Available at https://doi.org/10.1101/2020.02.07.937862. February 11, 2020; Accessed: February 13, 2020.
CDC COVID-19 Response Team, Jorden MA, Rudman SL, et al. Evidence for Limited Early Spread of COVID-19 Within the United States, January-February 2020. MMWR. Available at https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/solidarity-clinical-trial-for-covid-19-treatments. May 29, 2020; Accessed: June 1, 2020.
CDC. Coronavirus Disease 2019 (COVID-19): Recommendations for Cloth Face Covers. Centers for Disease Control and Prevention. Available at https://www.cdc.gov/coronavirus/2019-ncov/prevent-getting-sick/cloth-face-cover.html. April 3, 2020; Accessed: April 6, 2020.
Ferguson NM, Laydon D, Nedjati-Gilani G, Imai N, Ainslie K, Baguelin M, et al. Impact of non-pharmaceutical interventions (NPIs) to reduce COVID-19 mortality and healthcare demand. Imperial College COVID-19 Response Team. Available at https://www.imperial.ac.uk/media/imperial-college/medicine/sph/ide/gida-fellowships/Imperial-College-COVID19-NPI-modelling-16-03-2020.pdf. 2020 Mar 16; Accessed: March 18, 2020.
Honein MA, Christie A, Rose DA, et al. Summary of guidance for public health strategies to address high levels of community transmission of SARS-CoV-2 and related deaths, December 2020. MMWR Morb Mortal Wkly Rep. 2020 Dec 04. [Full Text].
CDC. Underlying medical conditions associated with high risk for severe COVID-19: Information for healthcare providers. Centers for Disease Control and Prevention. Available at https://www.cdc.gov/coronavirus/2019-ncov/hcp/clinical-care/underlyingconditions.html. 2021 Mar 29; Accessed: March 31, 2021.
CDC. 2019 Novel Coronavirus, Wuhan, China: Symptoms. CDC. Available at https://www.cdc.gov/coronavirus/2019-ncov/about/symptoms.html. January 26, 2020; Accessed: January 27, 2020.
Lauer SA, Grantz KH, Bi Q, Jones FK, Zheng Q, Meredith HR, et al. The Incubation Period of Coronavirus Disease 2019 (COVID-19) From Publicly Reported Confirmed Cases: Estimation and Application. Ann Intern Med. 2020 Mar 10. [Medline].
Wu Z, McGoogan JM. Characteristics of and Important Lessons From the Coronavirus Disease 2019 (COVID-19) Outbreak in China: Summary of a Report of 72 314 Cases From the Chinese Center for Disease Control and Prevention. JAMA. 2020 Feb 24. [Medline].
CDC. Symptoms of Coronavirus. CDC. Available at https://www.cdc.gov/coronavirus/2019-ncov/symptoms-testing/symptoms.html. May 13, 2020; Accessed: June 26, 2020.
Rabin RC. Lost Sense of Smell May Be Peculiar Clue to Coronavirus Infection. The New York Times. Available at https://www.nytimes.com/2020/03/22/health/coronavirus-symptoms-smell-taste.html. March 22, 2020; Accessed: March 24, 2020.
Spinato G, Fabbris C, Polesel J, Cazzador D, Borsetto D, Hopkins C, et al. Alterations in Smell or Taste in Mildly Symptomatic Outpatients With SARS-CoV-2 Infection. JAMA. 2020 Apr 22. [Medline].
CDC. 2019 Novel Coronavirus, Wuhan, China: Interim Healthcare Infection Prevention and Control Recommendations for Patients Under Investigation for 2019 Novel Coronavirus. CDC. Available at https://www.cdc.gov/coronavirus/2019-ncov/infection-control.html. January 18, 2020; Accessed: January 27, 2020.
Rizk JG, Forthal DN, Kalantar-Zadeh K, Mehra MR, Lavie CJ, Rizk Y, et al. Expanded Access Programs, compassionate drug use, and Emergency Use Authorizations during the COVID-19 pandemic. Drug Discov Today. 2020 Nov 27. [Medline]. [Full Text].
FDA. FDA Approves First Treatment for COVID-19. FDA.gov. 2020 Oct 22. Available at https://www.fda.gov/news-events/press-announcements/fda-approves-first-treatment-covid-19.
FDA. Fact sheet for healthcare providers emergency use authorization (EUA) of Veklury (remdesivir) for hospitalized pediatric patients weighing 3.5 kg to less than 40 kg or hospitalized pediatric patients less than 12 years of age weight at least 3.5 kg. fda.gov. Available at https://www.fda.gov/media/137566/download. October, 2020 (revised); Accessed: October 22, 2020.
RECOVERY Collaborative Group., Horby P, Lim WS, Emberson JR, et al. Dexamethasone in Hospitalized Patients with Covid-19. N Engl J Med. 2021 Feb 25. 384 (8):693-704. [Medline]. [Full Text].
McCreary EK, Pogue JM. COVID-19 Treatment: A Review of Early and Emerging Options. Open Forum Infectious Diseases (OFID). 2020 Mar 23. [Full Text].
[Guideline] Bhimraj A, Morgan RL, Shumaker AH, et al. Infectious Diseases Society of America Guidelines on the Treatment and Management of Patients with COVID-19. IDSA. Available at https://www.idsociety.org/practice-guideline/covid-19-guideline-treatment-and-management/. 2021 Mar 05; Accessed: March 12, 2021.
Sanders JM, Monogue ML, Jodlowski TZ, Cutrell JB. Pharmacologic Treatments for Coronavirus Disease 2019 (COVID-19): A Review. JAMA. 2020 Apr 13. [Medline]. [Full Text].
Barlow A, Landolf KM, Barlow B, Yeung SYA, Heavner JJ, Claassen CW, et al. Review of Emerging Pharmacotherapy for the Treatment of Coronavirus Disease 2019. Pharmacotherapy. 2020 Apr 7. [Medline]. [Full Text].
Jomah S, Asdaq SMB, Al-Yamani MJ. Clinical efficacy of antivirals against novel coronavirus (COVID-19): A review. J Infect Public Health. 2020 Aug 3. [Medline]. [Full Text].
Abutaleb Y. How the new coronavirus differs from SARS, measles and Ebola. The Washington Post. Available at https://www.washingtonpost.com/health/how-the-new-coronavirus-differs-from-sars-measles-and-ebola/2020/01/23/aac6bb06-3e1b-11ea-b90d-5652806c3b3a_story.html. January 23, 2020; Accessed: January 27, 2020.
Hui DS, I Azhar E, Madani TA, Ntoumi F, Kock R, Dar O, et al. The continuing 2019-nCoV epidemic threat of novel coronaviruses to global health - The latest 2019 novel coronavirus outbreak in Wuhan, China. Int J Infect Dis. 2020 Jan 14. 91:264-266. [Medline].
CDC. Coronavirus Disease 2019: Scientific Brief: SARS-CoV-2 and Potential Airborne Transmission. Centers for Disease Control and Prevention. Centers for Disease Control and Prevention. Available at https://www.cdc.gov/coronavirus/2019-ncov/more/scientific-brief-sars-cov-2.html. 2020 Oct 05; Accessed: October 9, 2020.
Morawska L, Milton DK. It is Time to Address Airborne Transmission of COVID-19. Clin Infect Dis. 2020 Jul 6. [Medline].
World Health Organization. Transmission of SARS-CoV-2: implications for infection prevention precautions. World Health Organization. Available at https://www.who.int/news-room/commentaries/detail/transmission-of-sars-cov-2-implications-for-infection-prevention-precautions. July 9, 2020; Accessed: July 13, 2020.
van Doremalen N, Bushmaker T, Morris DH, Holbrook MG, Gamble A, Williamson BN, et al. Aerosol and Surface Stability of SARS-CoV-2 as Compared with SARS-CoV-1. N Engl J Med. 2020 Mar 17. [Medline].
Chin AWH, Chu JTS, Perera MRA, et al. Stability of SARS-CoV-2 in different environmental conditions. The Lancet Microbe. April 2, 2020. [Full Text].
Zhou F, Yu T, Du R, Fan G, Liu Y, Liu Z, et al. Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study. Lancet. 2020 Mar 11. [Medline].
Liu Y, Yan LM, Wan L, Xiang TX, Le A, Liu JM, et al. Viral dynamics in mild and severe cases of COVID-19. Lancet Infect Dis. 2020 Mar 19. [Medline].
Zhou B, She J, Wang Y, Ma X. The duration of viral shedding of discharged patients with severe COVID-19. Clin Infect Dis. 2020 Apr 17. [Medline].
Mole B. Recovered COVID-19 patients test positive but not infectious, data finds. Ars Technica. Available at https://arstechnica.com/science/2020/05/feared-reactivation-of-covid-19-infections-disputed-by-new-data/. May 19, 2020; Accessed: June 1, 2020.
Aydillo T, Gonzalez-Reiche AS, Aslam S, van de Guchte A, Khan Z, Obla A, et al. Shedding of Viable SARS-CoV-2 after Immunosuppressive Therapy for Cancer. N Engl J Med. 2020 Dec 24. 383 (26):2586-2588. [Medline]. [Full Text].
Baang JH, Smith C, Mirabelli C, Valesano AL, Manthei DM, Bachman M, et al. Prolonged SARS-CoV-2 replication in an immunocompromised patient. J Infect Dis. 2020 Oct 22. [Medline]. [Full Text].
Li D, Jin M, Bao P, Zhao W, Zhang S. Clinical Characteristics and Results of Semen Tests Among Men With Coronavirus Disease 2019. JAMA Netw Open. 2020 May 1. 3 (5):e208292. [Medline].
Oran DP, Topol EJ. Prevalence of Asymptomatic SARS-CoV-2 Infection : A Narrative Review. Ann Intern Med. 2020 Sep 1. 173 (5):362-367. [Medline]. [Full Text].
Johansson MA, Quandelacy TM, Kada S, Prasad PV, Steele M, Brooks JT, et al. SARS-CoV-2 Transmission From People Without COVID-19 Symptoms. JAMA Netw Open. 2021 Jan 4. 4 (1):e2035057. [Medline]. [Full Text].
Zou L, Ruan F, Huang M, Liang L, Huang H, Hong Z, et al. SARS-CoV-2 Viral Load in Upper Respiratory Specimens of Infected Patients. N Engl J Med. 2020 Feb 19. [Medline].
WHO Coronavirus Disease (COVID-19) Dashboard. World Health Organization. Available at https://covid19.who.int/. 2021 Jun 25; Accessed: June 25, 2021.
CDC. Coronavirus Disease 2019 (COVID-19) – Cases in the U.S. Centers for Disease Control and Prevention (CDC). Available at https://covid.cdc.gov/covid-data-tracker/#cases_casesper100klast7days. 2021 Jun 25; Accessed: June 25, 2021.
Ahmad FB, Cisewski JA, Miniño A, Anderson RN. Provisional Mortality Data – United States, 2020. Centers for Disease Control and Prevention. MMWR Morb Mortal Wkly. 2021 Mar 31. [Full Text].
Feuer W, Higgins-Dunn N, Lovelace B. US now has more coronavirus cases than either China or Italy. CNBC. Available at https://www.cnbc.com/2020/03/26/usa-now-has-more-coronavirus-cases-than-either-china-or-italy.html. March 26, 2020; Accessed: March 27, 2020.
Price-Haywood EG, Burton J, Fort D, Seoane L. Hospitalization and Mortality among Black Patients and White Patients with Covid-19. N Engl J Med. 2020 Jun 25. 382 (26):2534-2543. [Medline]. [Full Text].
Zelner J, Trangucci R, Naraharisetti R, Cao A, Malosh R, Broen K, et al. Racial disparities in COVID-19 mortality are driven by unequal infection risks. Clin Infect Dis. 2020 Nov 21. [Medline]. [Full Text].
Tai DBG, Shah A, Doubeni CA, Sia IG, Wieland ML. The Disproportionate Impact of COVID-19 on Racial and Ethnic Minorities in the United States. Clin Infect Dis. 2020 Jun 20. [Medline]. [Full Text].
Cunningham JW, Vaduganathan M, Claggett BL, Jering KS, Bhatt AS, Rosenthal N, et al. Clinical Outcomes in Young US Adults Hospitalized With COVID-19. JAMA Intern Med. 2020 Sep 9. [Medline]. [Full Text].
Park YJ, Choe YJ, Park O, and the, COVID-19 National Emergency Response Center, Epidemiology and Case Management Team. Contact Tracing during Coronavirus Disease Outbreak, South Korea, 2020. Emerg Infect Dis. 2020 Oct. 26 (10):2465-2468. [Medline]. [Full Text].
Schwartz NG, Moorman AC, Makaretz A, Chang KT, Chu VT, Szablewski CM, et al. Adolescent with COVID-19 as the Source of an Outbreak at a 3-Week Family Gathering - Four States, June-July 2020. MMWR Morb Mortal Wkly Rep. 2020 Oct 9. 69 (40):1457-1459. [Medline]. [Full Text].
Castagnoli R, Votto M, Licari A, Brambilla I, Bruno R, Perlini S, et al. Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection in Children and Adolescents: A Systematic Review. JAMA Pediatr. 2020 Apr 22. [Medline].
Aronoff SC, Hall A, Del Vecchio MT. The Natural History of SARS-Cov-2 Related Multisystem Inflammatory Syndrome in Children (MIS-C): A Systematic Review. J Pediatric Infect Dis Soc. 2020 Sep 14. [Medline]. [Full Text].
Hoang A, Chorath K, Moreira A, Evans M, Burmeister-Morton F, Burmeister F, et al. COVID-19 in 7780 pediatric patients: A systematic review. EClinicalMedicine. 2020 Jul. 24:100433. [Medline]. [Full Text].
Ahmed M, Advani S, Moreira A, Zoretic S, Martinez J, Chorath K, et al. Multisystem inflammatory syndrome in children: A systematic review. EClinicalMedicine. 2020 Sep 4. 100527. [Medline]. [Full Text].
Children and COVID-19: State-Level Data Report. American Academy of Pediatrics. Available at https://services.aap.org/en/pages/2019-novel-coronavirus-covid-19-infections/children-and-covid-19-state-level-data-report/. 2021 Jun 17; Accessed: June 25, 2021.
Bixler D, Miller AD, Mattison CP, and the, Pediatric Mortality Investigation Team. SARS-CoV-2-Associated Deaths Among Persons Aged MMWR Morb Mortal Wkly Rep</i>. 2020 Sep 18. 69 (37):1324-1329. [Medline]. [Full Text].
Chao JY, Derespina KR, Herold BC, Goldman DL, Aldrich M, Weingarten J, et al. Clinical Characteristics and Outcomes of Hospitalized and Critically Ill Children and Adolescents with Coronavirus Disease 2019 at a Tertiary Care Medical Center in New York City. J Pediatr. 2020 Aug. 223:14-19.e2. [Medline]. [Full Text].
Han MS, Choi EH, Chang SH, Jin BL, Lee EJ, Kim BN, et al. Clinical Characteristics and Viral RNA Detection in Children With Coronavirus Disease 2019 in the Republic of Korea. JAMA Pediatr. 2020 Aug 28. [Medline]. [Full Text].
Jiang L, Tang K, Levin M, Irfan O, Morris SK, Wilson K, et al. COVID-19 and multisystem inflammatory syndrome in children and adolescents. Lancet Infect Dis. 2020 Nov. 20 (11):e276-e288. [Medline].
Feldstein LR, Tenforde MW, Friedman KG, and the, Overcoming COVID-19 Investigators. Characteristics and Outcomes of US Children and Adolescents With Multisystem Inflammatory Syndrome in Children (MIS-C) Compared With Severe Acute COVID-19. JAMA. 2021 Feb 24. [Medline]. [Full Text].
Delahoy MJ, Whitaker M, O’Halloran A, et al. Characteristics and maternal and birth outcomes of hospitalized pregnant women with laboratory-confirmed COVID-19 – COVID-NET, 13 states, March 1-August 22, 2020. MMWR Morb Mort Wkly Rep. 2020 Sep 18. [Full Text].
Marín Gabriel MA, Reyne Vergeli M, Caserío Carbonero S, Sole L, Carrizosa Molina T, Rivero Calle I, et al. Maternal, Perinatal and Neonatal Outcomes With COVID-19: A Multicenter Study of 242 Pregnancies and Their 248 Infant Newborns During Their First Month of Life. Pediatr Infect Dis J. 2020 Sep 11. [Medline].
Pierce-Williams RAM, Burd J, Felder L, Khoury R, Bernstein PS, Avila K, et al. Clinical course of severe and critical coronavirus disease 2019 in hospitalized pregnancies: a United States cohort study. Am J Obstet Gynecol MFM. 2020 Aug. 2 (3):100134. [Medline]. [Full Text].
Adhikari EH, Moreno W, Zofkie AC, MacDonald L, McIntire DD, Collins RRJ, et al. Pregnancy Outcomes Among Women With and Without Severe Acute Respiratory Syndrome Coronavirus 2 Infection. JAMA Netw Open. 2020 Nov 2. 3 (11):e2029256. [Medline].
Chambers C, Krogstad P, Bertrand K, Contreras D, Tobin NH, Bode L, et al. Evaluation for SARS-CoV-2 in Breast Milk From 18 Infected Women. JAMA. 2020 Aug 19. [Medline]. [Full Text].
Pace RM, Williams JE, Järvinen KM, Belfort MB, Pace CD, Lackey KA, et al. COVID-19 and human milk: SARS-CoV-2, antibodies, and neutralizing capacity. medRxiv. 2020 Sep 18. [Medline].
Dandachi D, Geiger G, Montgomery MW, and the, HIV-COVID-19 consortium. Characteristics, Comorbidities, and Outcomes in a Multicenter Registry of Patients with HIV and Coronavirus Disease-19. Clin Infect Dis. 2020 Sep 9. [Medline]. [Full Text].
Okoh AK, Bishburg E, Grinberg S, Nagarakanti S. COVID-19 Pneumonia in Patients With HIV: A Case Series. J Acquir Immune Defic Syndr. 2020 Sep 1. 85 (1):e4-e5. [Medline]. [Full Text].
Karmen-Tuohy S, Carlucci PM, Zervou FN, Zacharioudakis IM, Rebick G, Klein E, et al. Outcomes Among HIV-Positive Patients Hospitalized With COVID-19. J Acquir Immune Defic Syndr. 2020 Sep 1. 85 (1):6-10. [Medline]. [Full Text].
Ho HE, Peluso MJ, Margus C, Matias Lopes JP, He C, Gaisa MM, et al. Clinical outcomes and immunologic characteristics of Covid-19 in people with HIV. J Infect Dis. 2020 Jun 30. [Medline]. [Full Text].
Self WH, Tenforde MW, Stubblefield WB, and the, CDC COVID-19 Response Team IVY Network. Seroprevalence of SARS-CoV-2 among frontline health care personnel in a multistate hospital network – 13 academic medical centers, April-June 2020. MMWR Morb Mortal Wkly Rep. 2020 Aug 31. 69:[Full Text].
Barron E, Bakhai C, Kar P, Weaver A, Bradley D, Ismail H, et al. Associations of type 1 and type 2 diabetes with COVID-19-related mortality in England: a whole-population study. Lancet Diabetes Endocrinol. 2020 Aug 13. [Medline]. [Full Text].
O'Hearn M, Liu J, Cudhea F, Micha R, Mozaffarian D. Coronavirus Disease 2019 Hospitalizations Attributable to Cardiometabolic Conditions in the United States: A Comparative Risk Assessment Analysis. J Am Heart Assoc. 2021 Feb. 10 (5):e019259. [Medline]. [Full Text].
Kemp SA, Harvey WT, Lytras S, and the, COVID-19 Genomics UK (COG-UK) consortium. Recurrent emergence and transmission of a SARS-CoV-2 Spike deletion H69/V70. BioRxiv. 2020 Dec 21. [Full Text].
New and Emerging Respiratory Virus Threats Advisory Group (NERVTAG) statements and meeting minutes for SARS-CoV-2 variants (VUI-202012/01 [B.1.1.7]). www.gov.uk/government. Available at https://www.gov.uk/government/groups/new-and-emerging-respiratory-virus-threats-advisory-group. 2020 Dec 23; Accessed: December 30, 2020.
Volz E, Mishra S, Chand M, Barrett JC, Johnson R, Geidelberg L, et al. Report 42 - Transmission of SARS-CoV-2 Lineage B.1.1.7 in England: Insights from linking epidemiological and genetic data. Imperial College London, MRC Centre for Global Infectious Disease Analysis. Available at https://www.imperial.ac.uk/media/imperial-college/medicine/mrc-gida/2020-12-31-COVID19-Report-42-Preprint-VOC.pdf. 2020 Dec 31; Accessed: January 4, 2021.
Nelson G, Oleksandr B, Spilman P, Niazi K, Rabizadeh S, Soon-Shiong P. Molecular dynamic simulation reveals E484K mutation enhances spike RBD-ACE2 affinity and the combination of E484K, K417N and N401Y mutations (501Y.V2 variant) induces conformational change greater than N401Y mutant alone, potentially resulting in an escape mutant. bioRxiv. 2021 Jan 13. [Full Text].
Sabino EC, Buss LF, Carvalho MPS, Prete CA, Crispim MAE, Fraiji NA, et al. Resurgence of COVID-19 in Manaus, Brazil, despite high seroprevalence. Lancet. 2021 Jan 27. [Full Text].
Cherian S, Potdar V, Jadhav S, Yadav P, Gupta N, Das M, et al. Convergent evolution of SARS-CoV-2 spike mutations, L452R, E484Q and P681R, in the second wave of COVID-19 in Maharashtra, India. bioRxiv. 2021 May 03. [Full Text].
Edara VV, Lai L, Sahoo MK, Floyd K, Sibai M, Solis D, et al. Infection and vaccine-induced neutralizing antibody responses to the SARS-CoV-2 B.1.617.1 variant. bioRxiv. 2021 May 10. [Full Text].
Wiersinga WJ, Rhodes A, Cheng AC, Peacock SJ, Prescott HC. Pathophysiology, Transmission, Diagnosis, and Treatment of Coronavirus Disease 2019 (COVID-19): A Review. JAMA. 2020 Aug 25. 324 (8):782-793. [Medline].
Burke RM, Killerby ME, Newton S, Ashworth CE, Berns AL, Brennan S, et al. Symptom Profiles of a Convenience Sample of Patients with COVID-19 - United States, January-April 2020. MMWR Morb Mortal Wkly Rep. 2020 Jul 17. 69 (28):904-908. [Medline].
CDC. 2019 Novel Coronavirus, Wuhan, China: Interim Guidance for Healthcare Professionals. CDC. Available at https://www.cdc.gov/coronavirus/2019-nCoV/clinical-criteria.html. January 17, 2020; Accessed: January 27, 2020.
Williamson EJ, Walker AJ, Bhaskaran K, et al. OpenSAFELY: factors associated with COVID-19 death in 17 million patients. Nature. 2020 Jul 8. [Medline].
Hewitt J, Carter B, Vilches-Moraga A, et al. The effect of frailty on survival in patients with COVID-19 (COPE): a multicentre, European, observational cohort study. Lancet Public Health. 2020 Jun 30. [Medline].
Ellinghaus D, Degenhardt F, Bujanda L, et al. The ABO blood group locus and a chromosome 3 gene cluster associate with SARS-CoV-2 respiratory failure in an Italian-Spanish genome-wide association analysis. medRxiv. Available at https://www.medrxiv.org/content/10.1101/2020.05.31.20114991v1. June 2, 2020; Accessed: June 8, 2020.
Ellinghaus D, Degenhardt F, Bujanda L, et al. Genomewide Association Study of Severe Covid-19 With Respiratory Failure. NEJM. 2020 Jun 17. [Medline]. [Full Text].
Luers JC, Rokohl AC, Loreck N, Wawer Matos PA, Augustin M, Dewald F, et al. Olfactory and Gustatory Dysfunction in Coronavirus Disease 19 (COVID-19). Clin Infect Dis. 2020 May 1. [Medline].
Huang C, Wang Y, Li X, Ren L, Zhao J, Hu Y, et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet. 2020 Jan 24. [Medline].
Guan WJ, Ni ZY, Hu Y, et al. Clinical Characteristics of Coronavirus Disease 2019 in China. N Engl J Med. 2020 Feb 28. [Medline].
Chen N, Zhou M, Dong X, Qu J, Gong F, Han Y, et al. Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study. Lancet. 2020 Feb 15. 395 (10223):507-513. [Medline].
Wang D, Hu B, Hu C, Zhu F, Liu X, Zhang J, et al. Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus-Infected Pneumonia in Wuhan, China. JAMA. 2020 Feb 7. [Medline].
CDC. Long-Term Effects of COVID-19. Centers for Disease Control and Prevention. Available at https://www.cdc.gov/coronavirus/2019-ncov/long-term-effects.html. 2020 Nov 13; Accessed: December 11, 2020.
[Guideline] COVID-19 Treatment Guidelines Panel. Clinical Spectrum of SARS-CoV-2 Infection. National Institutes of Health. Available at https://www.covid19treatmentguidelines.nih.gov/overview/clinical-spectrum/. 2020 Dec 17; Accessed: January 7, 2021.
[Guideline] COVID-19 rapid guideline: managing the long-term effects of COVID-19. National Institute for Health and Care Excellence (NICE). Available at https://www.nice.org.uk/guidance/NG188. 2020 Dec 18; Accessed: January 7, 2021.
Davis HE, Assaf GS, McCorkell L, Wie H, Low RJ, Re'em Y, et al. Characterizing Long COVIC in an international cohort: 7 months of symptoms and their impact. medRxiv. 2020 Dec 27. [Full Text].
Carvalho-Schneider C, Laurent E, Lemaignen A, Beaufils E, Bourbao-Tournois C, Laribi S, et al. Follow-up of adults with noncritical COVID-19 two months after symptom onset. Clin Microbiol Infect. 2020 Oct 5. [Medline]. [Full Text].
Huang C, Huang L, Wang Y, Xia L, Ren L, Xiaoying G, et al. 6-month consequences of COVID-19 in patients discharged from hospital: a cohort study. Lancet. 2021 Jan 08. [Full Text].
Zhao YM, Shang YM, Song WB, Li QQ, Xie H, Xu QF, et al. Follow-up study of the pulmonary function and related physiological characteristics of COVID-19 survivors three months after recovery. EClinicalMedicine. 2020 Aug. 25:100463. [Medline]. [Full Text].
van den Borst B, Peters JB, Brink M, Schoon Y, Bleeker-Rovers CP, Schers H, et al. Comprehensive health assessment three months after recovery from acute COVID-19. Clin Infect Dis. 2020 Nov 21. [Medline]. [Full Text].
Logue JK, Franko NM, McCulloch DJ, McDonald D, Magedson A, Wolf CR, et al. Sequelae in Adults at 6 Months After COVID-19 Infection. JAMA Netw Open. 2021 Feb 1. 4 (2):e210830. [Medline].
Datta SD, Talwar A, Lee JT. A Proposed Framework and Timeline of the Spectrum of Disease Due to SARS-CoV-2 Infection: Illness Beyond Acute Infection and Public Health Implications. JAMA. 2020 Dec 8. 324 (22):2251-2252. [Medline]. [Full Text].
McFadyen JD, Stevens H, Peter K. The Emerging Threat of (Micro)Thrombosis in COVID-19 and Its Therapeutic Implications. Circ Res. 2020 Jul 31. 127 (4):571-587. [Medline]. [Full Text].
Kotecha T, Knight DS, Razvi Y, Kumar K, Vimalesvaran K, Thornton G, et al. Patterns of myocardial injury in recovered troponin-positive COVID-19 patients assessed by cardiovascular magnetic resonance. Eur Heart J. 2021 Feb 18. [Medline]. [Full Text].
Kang H, Wang Y, Tong Z, Liu X. Retest positive for SARS-CoV-2 RNA of "recovered" patients with COVID-19: Persistence, sampling issues, or re-infection?. J Med Virol. 2020 Jun 3. [Medline]. [Full Text].
Goodman B. First Confirmed Cases of COVID-19 Reinfections in US. Medscape Medical News. 2020 Oct 12. Available at https://www.medscape.com/viewarticle/939003.
Larson D, Brodniak SL, Voegtly LJ, Cer RZ, Glang LA, Malagon FJ, et al. A Case of Early Re-infection with SARS-CoV-2. Clin Infect Dis. 2020 Sep 19. [Medline]. [Full Text].
To KK, Hung IF, Ip JD, Chu AW, Chan WM, Tam AR, et al. COVID-19 re-infection by a phylogenetically distinct SARS-coronavirus-2 strain confirmed by whole genome sequencing. Clin Infect Dis. 2020 Aug 25. [Medline]. [Full Text].
Gousseff M, Penot P, Gallay L, in behalf of the COCOREC study group. Clinical recurrences of COVID-19 symptoms after recovery: Viral relapse, reinfection or inflammatory rebound?. J Infect. 2020 Jun 30. [Medline]. [Full Text].
Tillett RL, Sevinsky JR, Hartley PD, Kerwin H, rawford N, Gorzalski A, et al. Genomic evidence for reinfection with SARS-CoV-2: a case study. Lancet Inf Dis. 2020 Oct 12. [Full Text].
CDC. 2019 Novel Coronavirus, Wuhan, China: Frequently Asked Questions and Answers. CDC. Available at https://www.cdc.gov/coronavirus/2019-ncov/faq.html. January 27, 2020; Accessed: January 27, 2020.
FDA. Coronavirus (COVID-19) Update: Daily Roundup. fda.gov. Available at https://www.fda.gov/news-events/press-announcements/coronavirus-covid-19-update-daily-roundup. March 23, 2020; Accessed: March 31, 2020.
Wu C, Chen X, Cai Y, Xia J, Zhou X, Xu S, et al. Risk Factors Associated With Acute Respiratory Distress Syndrome and Death in Patients With Coronavirus Disease 2019 Pneumonia in Wuhan, China. JAMA Intern Med. 2020 Mar 13. [Medline].
Shi H, Han X, Jiang N, Cao Y, Alwalid O, Gu J, et al. Radiological findings from 81 patients with COVID-19 pneumonia in Wuhan, China: a descriptive study. Lancet Infect Dis. 2020 Feb 24. [Medline].
Zhao W, Zhong Z, Xie X, Yu Q, Liu J. Relation Between Chest CT Findings and Clinical Conditions of Coronavirus Disease (COVID-19) Pneumonia: A Multicenter Study. AJR Am J Roentgenol. 2020 Mar 3. 1-6. [Medline].
Bai HX, Hsieh B, Xiong Z, Halsey K, Choi JW, Tran TML, et al. Performance of radiologists in differentiating COVID-19 from viral pneumonia on chest CT. Radiology. 2020 Mar 10. 200823. [Medline].
ACR. ACR Recommendations for the use of Chest Radiography and Computed Tomography (CT) for Suspected COVID-19 Infection. American College of Radiology. Available at https://www.acr.org/Advocacy-and-Economics/ACR-Position-Statements/Recommendations-for-Chest-Radiography-and-CT-for-Suspected-COVID19-Infection. March 22, 2020; Accessed: April 2, 2020.
Hu Z, Song C, Xu C, Jin G, Chen Y, Xu X, et al. Clinical characteristics of 24 asymptomatic infections with COVID-19 screened among close contacts in Nanjing, China. Sci China Life Sci. 2020 Mar 4. [Medline].
Wang Y, Liu Y, Liu L, Wang X, Luo N, Ling L. Clinical outcome of 55 asymptomatic cases at the time of hospital admission infected with SARS-Coronavirus-2 in Shenzhen, China. J Infect Dis. 2020 Mar 17. [Medline].
Li M, Lei P, Zeng B, Li Z, Yu P, Fan B, et al. Coronavirus Disease (COVID-19): Spectrum of CT Findings and Temporal Progression of the Disease. Acad Radiol. 2020 Mar 20. [Medline].
Wong HYF, Lam HYS, Fong AH, Leung ST, Chin TW, Lo CSY, et al. Frequency and Distribution of Chest Radiographic Findings in COVID-19 Positive Patients. Radiology. 2019 Mar 27. 201160. [Medline].
Bogoch II, Watts A, Thomas-Bachli A, Huber C, Kraemer MUG, Khan K. Pneumonia of Unknown Etiology in Wuhan, China: Potential for International Spread Via Commercial Air Travel. J Travel Med. 2020 Jan 14. [Medline].
FDA News Release. FDA Reissues Emergency Use Authorization for Convalescent Plasma. U.S. Food and Drug Administration. Available at https://www.fda.gov/media/141477/download. 2020 Nov 30; Accessed: December 8, 2020.
CDC. 2019 Novel Coronavirus, Wuhan, China: Prevention & Treatment. CDC. Available at https://www.cdc.gov/coronavirus/2019-ncov/about/prevention-treatment.html. January 26, 2020; Accessed: January 27, 2020.
WHO. The use of non-steroidal anti-inflammatory drugs (NSAIDs) in patients with COVID-19. WHO. Available at https://www.who.int/news-room/commentaries/detail/the-use-of-non-steroidal-anti-inflammatory-drugs-(nsaids)-in-patients-with-covid-19. April 19, 2020; Accessed: June 16, 2020.
Gordon DE, Jang GM, Bouhaddou M, Xu J, Obernier K, O’Mera MJ, et al. A SARS-CoV-2-Human Protein-Protein Interaction Map Reveals Drug Targets and Potential Drug-Repurposing. bioRxiv. Available at https://www.biorxiv.org/content/10.1101/2020.03.22.002386v1. 2020 Mar 22; Accessed: March 23, 2020.
I-SPY COVID-19 TRIAL: An Adaptive Platform Trial for Critically Ill Patients (I-SPY_COVID). ClinicalTrials.gov. Available at https://clinicaltrials.gov/ct2/show/NCT04488081. 2020 Aug 12; Accessed: August 25, 2020.
Arshad U, Pertinez H, Box H, Tatham L, Rajoki RKR, Curley P, et al. Prioritisation of potential anti-SARS-CoV-2 drug repurposing opportunities based on ability to achieve adequate target site concentrations derived from their established human pharmacokinetics. medRxiv. 2020 Apr 22. [Full Text].
World Health Organization. “Solidarity” clinical trial for COVID-19 treatments. WHO. Available at https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/solidarity-clinical-trial-for-covid-19-treatments. 2020 Oct 16; Accessed: October 16, 2020.
WHO Solidarity Trial Consortium. Repurposed Antiviral Drugs for Covid-19 - Interim WHO Solidarity Trial Results. N Engl J Med. 2020 Dec 2. [Medline]. [Full Text].
Kalil AC. Treating COVID-19-Off-Label Drug Use, Compassionate Use, and Randomized Clinical Trials During Pandemics. JAMA. 2020 Mar 24. [Medline]. [Full Text].
Rome BN, Avorn J. Drug Evaluation during the Covid-19 Pandemic. N Engl J Med. 2020 Apr 14. [Medline]. [Full Text].
Marcia Frellick. Key Drugs Join PPEs on List of Front-Line Shortages. Medscape Medical News. 2020 Apr 02. Available at https://www.medscape.com/viewarticle/928039.
Live Updates: Which Drugs Are In Shortage Because of COVID-19?. GoodRx. Available at https://www.goodrx.com/blog/covid-19-drug-shortages-updates/. Accessed: April 15, 2020.
Wilson FP. Hydroxychloroquine for COVID-19: What’s the Evidence? (Commentary). Medscape Medical News and Perspectives. 2020 Mar 25. Available at https://www.medscape.com/viewarticle/927342.
CDC. Coronavirus Disease 2019 (COVID-19): Community-Related Exposures. Centers for Disease Control and Prevention. Available at https://www.cdc.gov/coronavirus/2019-ncov/php/public-health-recommendations.html. March 30, 2020; Accessed: April 2, 2020.
CDC. Coronavirus Disease 2019 (COVID-19): Travel-Associated Exposures. Centers for Disease Control and Prevention. Available at https://www.cdc.gov/coronavirus/2019-ncov/php/risk-assessment.html. March 30, 2020; Accessed: April 3, 2020.
Leung NHL, Chu DKW, Shiu EYC, et al. Respiratory virus shedding in exhaled breath and efficacy of face masks. Nat Med. 2020. [Full Text].
Smith JD, MacDougall CC, Johnstone J, Copes RA, Schwartz B, Garber GE. Effectiveness of N95 respirators versus surgical masks in protecting health care workers from acute respiratory infection: a systematic review and meta-analysis. CMAJ. 2016 May 17. 188 (8):567-574. [Medline].
TLR 2/6/9 agonist PUL-042. NCI Drug Dictionary. Available at https://www.cancer.gov/publications/dictionaries/cancer-drug/def/tlr-2-6-9-agonist-pul-042. Accessed: 2020 Apr 13.
The Use PUL-042 Inhalation Solution to Prevent COVID-19 in Adults Exposed to SARS-CoV-2. ClinicalTrials.gov. Available at https://clinicaltrials.gov/ct2/show/NCT04313023. 2020 Mar 24;
The Use of PUL-042 Inhalation Solution to Reduce the Severity of COVID-19 in Adults Positive for SARS-CoV-2 Infection. ClinicalTrials.gov. Available at https://clinicaltrials.gov/ct2/show/NCT04312997?term=PUL-042&cond=COVID&cntry=US&draw=2&rank=2. 2020 May 07; Accessed: May 8, 2020.
FDA. Coronavirus (COVID-19) Update: FDA Issues Emergency Use Authorization for Potential COVID-19 Treatment. fda.gov. Available at https://www.fda.gov/news-events/press-announcements/coronavirus-covid-19-update-fda-issues-emergency-use-authorization-potential-covid-19-treatment. May 01, 2020; Accessed: May 01, 2020.
COVID-19 Update: FDA Broadens Emergency Use Authorization for Veklury (remdesivir) to Include All Hospitalized Patients for Treatment of COVID-19. US Food and Drug Administration. 2020 Aug 28. Available at https://www.fda.gov/news-events/press-announcements/covid-19-update-fda-broadens-emergency-use-authorization-veklury-remdesivir-include-all-hospitalized?utm_campaign=FDA%20Broadens%20Emergency%20Use%20Authorization%20for%20Veklury%20%28Remdesivir%29%20to%.
Study in participants with early stage coronavirus disease 2019 (COVID-19) to evaluate the safety, efficacy, and pharmacokinetics of remdesivir administered by inhalation. ClinicalTrials.gov. Available at https://www.clinicaltrials.gov/ct2/show/NCT04539262. 2020 Dec 09; Accessed: January 6, 2021.
Holshue ML, DeBolt C, Lindquist S, and, the Washington State 2019-nCoV Case Investigation Team. First Case of 2019 Novel Coronavirus in the United States. N Engl J Med. 2020 Mar 5. 382 (10):929-936. [Medline].
National Institutes of Health. NIH clinical trial of remdesivir to treat COVID-19 begins. U.S. Department of Health and Human Services. Available at https://www.nih.gov/news-events/news-releases/nih-clinical-trial-remdesivir-treat-covid-19-begins. 2020 Feb 25; Accessed: March 24, 2020.
Beigel JH, Tomashek KM, Dodd LE, Mehta AK, Zingman BS, Kalil AC, et al. Remdesivir for the Treatment of Covid-19 - Final Report. N Engl J Med. 2020 Oct 8. [Medline]. [Full Text].
Harrington DP, Baden LR, Hogan JW. A Large, Simple Trial Leading to Complex Questions. N Engl J Med. 2020 Dec 2. [Medline]. [Full Text].
Goldman JD, Lye DCB, Hui DS, Marks KM, Bruno R, Montejano R, et al. Remdesivir for 5 or 10 Days in Patients with Severe Covid-19. N Engl J Med. November 5, 2020. 383:1827-1837. [Medline]. [Full Text].
Spinner CD, Gottlieb RL, Criner GJ, and the, GS-US-540-5774 Investigators. Effect of Remdesivir vs Standard Care on Clinical Status at 11 Days in Patients With Moderate COVID-19: A Randomized Clinical Trial. JAMA. 2020 Aug 21. [Medline]. [Full Text].
Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Efficacy of Remdesivir (GS-5734) in Participants From Birth to < 18 Years of Age With Coronavirus Disease 2019 (COVID-19) (CARAVAN). ClinicalTrials.gov. Available at https://www.clinicaltrials.gov/ct2/show/NCT04431453. 2020 Jun 01; Accessed: July 14, 2020.
Chiotos K, Hayes M, Kimberlin DW, Jones SB, James SH, Pinninti SG, et al. Multicenter interim guidance on use of antivirals for children with COVID-19/SARS-CoV-2. J Pediatric Infect Dis Soc. 2020 Sep 12. [Medline]. [Full Text].
Burwick RM, Yawetz S, Stephenson KE, Collier AY, Sen P, Blackburn BG, et al. Compassionate Use of Remdesivir in Pregnant Women with Severe Covid-19. Clin Infect Dis. 2020 Oct 8. [Medline]. [Full Text].
McCoy JA, Short WR, Srinivas SK, Levine LD, Hirshberg A. Compassionate use of remdesivir for treatment of severe coronavirus disease 2019 in pregnant women at a United States academic center. Am J Obstet Gynecol MFM. 2020 Aug. 2 (3):100164. [Medline]. [Full Text].
Efficacy and Safety of Molnupiravir (MK-4482) in Non-Hospitalized Adult Participants With COVID-19. ClinicalTrials.gov. Available at https://www.clinicaltrials.gov/ct2/show/NCT04575597. 2021 Mar 12; Accessed: March 12, 2021.
Ivashchenko AA, Dmitriev KA, Vostokova NV, Azarova VN, Blinow AA, Egorova AN, et al. AVIFAVIR for Treatment of Patients with Moderate COVID-19: Interim Results of a Phase II/III Multicenter Randomized Clinical Trial. Clin Infect Dis. 2020 Aug 9. [Medline]. [Full Text].
Oral favipiravir compared to placebo in subjects with mild COVID-19. ClinicalTrials.gov. Available at https://www.clinicaltrials.gov/ct2/show/NCT04346628. 2020 Oct 05; Accessed: December 3, 2020.
Study of the use of favipiravir in hospitalized subjects with COVID-19. ClinicalTrials.gov. Available at https://www.clinicaltrials.gov/ct2/show/NCT04358549. 2020 Nov 06; Accessed: December 3, 2020.
Control of COVID-19 outbreaks in long term care. ClinicalTrials.gov. Available at https://clinicaltrials.gov/ct2/show/NCT04448119. 2020 Jun 25; Accessed: August 11, 2020.
Trial to Evaluate the Efficacy and Safety of Nitazoxanide (NTZ) for Post-Exposure Prophylaxis of COVID-19 and Other Viral Respiratory Illnesses in Elderly Residents of Long-Term Care Facilities (LTCF). ClinicalTrials.gov. Available at https://clinicaltrials.gov/ct2/show/NCT04343248?term=nitazoxanide&recrs=ab&cond=COVID&draw=2&rank=6. 2020 Apr 16; Accessed: April 28, 2020.
Trial to Evaluate the Efficacy and Safety of Nitazoxanide (NTZ) for Pre- or Post Exposure Prophylaxis of COVID-19 and Other Viral Respiratory Illnesses (VRI) in Healthcare Workers. ClinicalTrials.gov. Available at https://clinicaltrials.gov/ct2/show/NCT04359680?term=nitazoxanide&recrs=ab&cond=COVID&draw=2&rank=5. 2020 Apr 24; Accessed: April 28, 2020.
Romark initiates new phase 3 clinical trial of NT-300 for the treatment of COVID-19. Romark Pharmaceuticals. 2020 Aug 11. Available at https://www.romark.com/romark-initiates-new-phase-3-clinical-trial-of-nt-300-for-the-treatment-of-covid-19/.
Niclosamide in moderate COVID-19. ClinicalTrials.gov. Available at https://clinicaltrials.gov/ct2/show/NCT04436458. 2020 Jun 18; Accessed: August 7, 2020.
ANA Therapeutics begins phase 2/3 clinical trial of proprietary oral niclosamide formulation to treat COVID-19. Businesswire. 2020 Oct 26. Available at https://www.businesswire.com/news/home/20201026005569/en/ANA-Therapeutics-Begins-Phase-23-Clinical-Trial-of-Proprietary-Oral-Niclosamide-Formulation-to-Treat-COVID-19.
Ingraham NE, Lotfi-Emran S, Thielen BK, Techar K, Morris RS, Holtan SG, et al. Immunomodulation in COVID-19. Lancet Respir Med. 2020 May 4. [Medline]. [Full Text].
Rizk JG, Kalantar-Zadeh K, Mehra MR, Lavie CJ, Rizk Y, Forthal DN. Pharmaco-Immunomodulatory Therapy in COVID-19. Drugs. 2020 Sep. 80 (13):1267-1292. [Medline]. [Full Text].
Wagner JL, Veve MP, Barber KE. Using IL-6 inhibitors to treat COVID-19. ContagionLive. Available at https://www.contagionlive.com/publications/contagion/2020/august/using-il6-inhibitors-to-treat-covid19?ekey=c2NiZXJnbWFuQG5lYnJhc2thbWVkLmNvbQ. 2020 Aug 17; Accessed: August 18, 2020.
[Guideline] NIH. The COVID-19 Treatment Guidelines Panel’s Statement on the Use of Tocilizumab (and Other Interleukin-6 Inhibitors) for the Treatment of COVID-19. COVID-19 Treatment Guidelines. Available at https://www.covid19treatmentguidelines.nih.gov/immune-based-therapy/interleukin-6-inhibitors/. 2021 Mar 05; Accessed: March 12, 2021.
Salama C, Han J, Yau L, Reiss WG, Kramer B, Neidhart JD, et al. Tocilizumab in Patients Hospitalized with Covid-19 Pneumonia. N Engl J Med. 2021 Jan 7. 384 (1):20-30. [Medline]. [Full Text].
REMAP-CAP Investigators., Gordon AC, Mouncey PR, Al-Beidh F, et al. Interleukin-6 Receptor Antagonists in Critically Ill Patients with Covid-19. N Engl J Med. 2021 Apr 22. 384 (16):1491-1502. [Medline]. [Full Text].
RECOVERY Collaborative Group. Tocilizumab in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial. Lancet. 2021 May 1. 397 (10285):1637-1645. [Medline]. [Full Text].
Rosas IO, Bräu N, Waters M, Go RC, Hunter BD, Bhagani S, et al. Tocilizumab in Hospitalized Patients with Severe Covid-19 Pneumonia. N Engl J Med. 2021 Apr 22. 384 (16):1503-1516. [Medline]. [Full Text].
Rubin EJ, Longo DL, Baden LR. Interleukin-6 Receptor Inhibition in Covid-19 - Cooling the Inflammatory Soup. N Engl J Med. 2021 Apr 22. 384 (16):1564-1565. [Medline]. [Full Text].
[Guideline] NIH. Interleukin-1 Inhibitors. COVID-19 Treatment Guidelines. Available at https://www.covid19treatmentguidelines.nih.gov/immune-based-therapy/interleukin-1-inhibitors/. 2020 Jun 11; Accessed: June 16, 2020.
Intereukin-7 to improve clinical outcomes in lymphopenic patients with COVID-19 infection FR BL Cohort (ILIAD-7-FR). ClinicalTrials.gov. Available at https://clinicaltrials.gov/ct2/show/NCT04407689. 2020 Jun 22; Accessed: November 16, 2020.
Interleukin-7 (CYT107 to improve clinical outcomes in lymphopenic patients with COVID-19 infection UK cohort (ILIAD-7-UK). ClinicalTrials.gov. Available at https://clinicaltrials.gov/ct2/show/NCT04379076. 2020 May 15; Accessed: November 16, 2020.
Laterre PF, François B, Collienne C, Hantson P, Jeannet R, Remy KE, et al. Association of Interleukin 7 Immunotherapy With Lymphocyte Counts Among Patients With Severe Coronavirus Disease 2019 (COVID-19). JAMA Netw Open. 2020 Jul 1. 3 (7):e2016485. [Medline]. [Full Text].
Stebbing J, Phelan A, Griffin I, Tucker C, Oechsle O, Smith D, et al. COVID-19: combining antiviral and anti-inflammatory treatments. Lancet Infect Dis. 2020 Apr. 20 (4):400-402. [Medline]. [Full Text].
Richardson P, Griffin I, Tucker C, Smith D, Oechsle O, Phelan A, et al. Baricitinib as potential treatment for 2019-nCoV acute respiratory disease. Lancet. 2020 Feb 15. 395 (10223):e30-e31. [Medline]. [Full Text].
Stebbing J, Krishnan V, de Bono S, Ottaviani S, Casalini G, Richarson PJ, et al. Mechanism of baricitinib supports artificial intelligence-predicted testing in COVID-19 patients. 2020 Apr 15. [Full Text].
FDA. Fact sheet for healthcare providers emergency use authorization (EUA) of baricitinib. fda.gov. Available at https://www.fda.gov/media/143823/download. November 2020; Accessed: November 19, 2020.
Kalil AC, Patterson TF, Mehta AK, Tomashek KM, Wolfe CR, Ghazaryan V, et al. Baricitinib plus Remdesivir for Hospitalized Adults with Covid-19. N Engl J Med. 2020 Dec 11. [Medline]. [Full Text].
[Guideline] Clinical management of severe acute respiratory infection when novel coronavirus (nCoV) infection is suspected. World Health Organization. Available at https://www.who.int/publications-detail/clinical-management-of-severe-acute-respiratory-infection-when-novel-coronavirus-(ncov)-infection-is-suspected. 2020 Mar 13; Accessed: March 24, 2020.
Russell CD, Millar JE, Baillie JK. Clinical evidence does not support corticosteroid treatment for 2019-nCoV lung injury. Lancet. 2020 Feb 15. 395 (10223):473-475. [Medline].
[Guideline] Alhazzani W, Evans L, Alshamsi F, Møller MH, Ostermann M, Prescott HC, et al. Surviving Sepsis Campaign Guidelines on the Management of Adults With Coronavirus Disease 2019 (COVID-19) in the ICU: First Update. Crit Care Med. 2021 Mar 1. 49 (3):e219-e234. [Medline]. [Full Text].
WHO Rapid Evidence Appraisal for COVID-19 Therapies (REACT) Working Group. Association Between Administration of Systemic Corticosteroids and Mortality Among Critically Ill Patients With COVID-19: A Meta-analysis. JAMA. 2020 Sep 2. [Medline]. [Full Text].
Prescott HC, Rice TW. Corticosteroids in COVID-19 ARDS: Evidence and Hope During the Pandemic. JAMA. 2020 Sep 2. [Medline]. [Full Text].
[Guideline] WHO. Corticosteroids for COVID-19 – Living Guidance. World Health Organization. Available at https://www.who.int/publications/i/item/WHO-2019-nCoV-Corticosteroids-2020.1. 2020 Sep 02; Accessed: September 3, 2020.
Fact Sheet for Health Care Providers - Emergency Use Authorization (EUA) of COVID-19 Convalescent Plasma for Treatment of COVID-19 in Hospitalized Patients. US Food and Drug Administration. Available at https://www.fda.gov/media/141478/download. 2020 Aug 23; Accessed: August 23, 2020.
NIH COVID-19 Treatment Guidelines Panel. Statement on the emergency use authorization of convalescent plasma for the treatment of COVID-19. National Institutes of Health. Available at https://www.covid19treatmentguidelines.nih.gov/statement-on-convalescent-plasma-eua/. 2020 Oct 09; Accessed: January 9, 2021.
NIAID. NIH clinical trial testing remdesivir plus interferon beta-1a for COVID-19 treatment begins. National Institutes of Health. Available at https://www.niaid.nih.gov/news-events/nih-clinical-trial-testing-remdesivir-plus-interferon-beta-1a-covid-19-treatment-begins. 2020 Aug 05; Accessed: August 7, 2020.
Adaptive COVID-19 Treatment Trial 3 (ACTT-3). ClinicalTrials.gov. Available at https://clinicaltrials.gov/ct2/show/NCT04492475. 2020 Aug 07; Accessed: August 7, 2020.
Schönbeck U, Libby P. Inflammation, immunity, and HMG-CoA reductase inhibitors: statins as antiinflammatory agents?. Circulation. 2004 Jun 1. 109 (21 Suppl 1):II18-26. [Medline]. [Full Text].
Hariyanto TI, Kurniawan A. Statin therapy did not improved the in-hospital outcome of coronavirus disease 2019 (COVID-19) infection. Diabetes Metab Syndr. 2020 Aug 26. 14(6):1613-1615. [Medline]. [Full Text].
Kow CS, Hasan SS. Meta-analysis of Effect of Statins in Patients with COVID-19. Am J Cardiol. 2020 Aug 12. [Medline]. [Full Text].
Castiglione V, Chiriacò M, Emdin M, Taddei S, Vergaro G. Statin therapy in COVID-19 infection. Eur Heart J Cardiovasc Pharmacother. 2020 Jul 1. 6 (4):258-259. [Medline]. [Full Text].
[Guideline] NIH. Covid-19 Treatment Guidelines - Adjunctive Therapy. National Institutes of Health. Available at https://www.covid19treatmentguidelines.nih.gov/adjunctive-therapy/. 2020 Jul 17; Accessed: July 31, 2020.
Yao JS, Paguio JA, Dee EC, Tan HC, Moulick A, Milazzo C, et al. The minimal effect of zinc on the survival of hospitalized patients with Covid-19: an observational study. Chest. 2020 Jul 22. [Medline]. [Full Text].
Meltzer DO, Best TJ, Zhang H, Vokes T, Arora V, Solway J. Association of Vitamin D Status and Other Clinical Characteristics With COVID-19 Test Results. JAMA Netw Open. 2020 Sep 1. 3 (9):e2019722. [Medline]. [Full Text].
Sahota O. Understanding vitamin D deficiency. Age Ageing. 2014 Sep. 43 (5):589-91. [Medline]. [Full Text].
NRx Pharmaceuticals announces positive results for Zyesami (aviptadil acetate) and submits emergency use authorization application to US Food and Drug Administration to treat critical COIVD-19 patients suffering from respiratory failure. NeuroRx Pharmaceuticals. 2021 Jun 01. Available at https://ir.nrxpharma.com/news-events/press-releases/detail/69/nrx-pharmaceuticals-announces-positive-results-for.
Inhaled aviptadil for the treatment of moderate and severe COVID-19 (AVICOVID-2). ClinicalTrials.gov. Available at https://clinicaltrials.gov/ct2/show/NCT04360096. 2021 Mar 11; Accessed: March 30, 2021.
Temesgen Z, Burger CD, Baker J, Polk C, Libertin C, Kelley C, et al. Lenzilumab efficacy and safety in newly hospitalized COVID-19 subjects: Results from the LIVE-AIR phase 3 randomized double-blind placebo-controlled trial. medRxiv. 2021 May 05. [Full Text].
Study of sargramostim in patients with COVID-19 (iLeukPulm). ClinicalTrials.gov. Available at https://www.clinicaltrials.gov/ct2/show/NCT04411680. 2021 Mar 02; Accessed: March 30, 2021.
A study to assess the efficacy and safety of gimsilumab in subjects with lung injury or acute respiratory distress syndrome secondary to coronavirus disease 2019. ClinicalTrials.gov. Available at https://clinicaltrials.gov/ct2/show/NCT04351243?term=gimsilumab&draw=2&rank=1. 2020 Dec 03; Accessed: March 31, 2021.
Pupim L, Wang TS, Hudock K, Denson J, Fourie N, Hercilla Vasquez L, et al. Mavrilimumab improves outcomes in phase 2 trial in non-mechanically-ventilated patients with severe COVID-19 pneumonia and systemic hyperinflammation. Presented at the 2021 European Congress of Rheumatology. Ann Rheum Dis. 2021 Jun 05. [Full Text].
Patel J, Beishuizen A , Ruiz XB, Boughanmi H, Cahn A, Criner GJ, et al. A randomized trial of otilimab in severe COVID-19 pneumonia (OSCAR). medRxiv. 2021 Apr 17. [Full Text].
A Randomized, Double-blind, Placebo-controlled Study to Investigate the Efficacy of Tradipitant in Treating Inflammatory Lung Injury and Improving Clinical Outcomes Associated With Severe or Critical COVID-19. (NCT04326426). ClinicalTrials.gov. Available at https://www.clinicaltrials.gov/ct2/show/NCT04326426?term=tradipitant&cond=COVID&draw=2&rank=1. 2020 Mar 30; Accessed: 2020 Apr 03.
Vanda Pharmaceuticals’ interim analysis from ODYSSEY study shows tradipitant may accelerate clinical improvement in patients with COVID-19 pneumonia. Vanda Pharmaceuticals. 2020 Aug 18. Available at https://vandapharmaceuticalsinc.gcs-web.com/node/14256/pdf.
Aprepitant injectable emulsion in patients with COVID-19 (GUARDS-1). ClinicalTrials.gov. Available at https://www.clinicaltrials.gov/ct2/show/NCT04470622. 2020 Jul 17; Accessed: July 23, 2020.
FDA grants fast track designation for remestemcel-L in the treatment of acute respiratory distress syndrome due to COVID-19. Mesoblast. 2020 Dec 01. Available at https://investorsmedia.mesoblast.com/static-files/046bf826-c5bf-4606-a0b2-0420f8c7a933.
MSCs in COVID-19 ARDS. ClinicalTrials.gov. Available at https://www.clinicaltrials.gov/ct2/show/NCT04371393. 2020 Nov 06; Accessed: December 3, 2020.
U.S. FDA clears Pluristem’s IND application for phase II COVID-19 study. Pluristem Therapeutics, Inc. 2020 May 08. Available at https://www.pluristem.com/wp-content/uploads/2020/05/FDA-Clearance-COVID-19-FINAL.pdf.
NantKwest announces FDA authorization of IND application for mesenchymal stem cell product for the treatment of severe COVID-19 patients. NantKwest. 2020 May 18. Available at https://nantkwest.com/nantkwest-announces-fda-authorization-of-ind-application-for-mesenchymal-stem-cell-product-for-the-treatment-of-severe-covid-19-patients/.
Efficacy and safety study of allogeneic HB-adMSCs for the treatment of COVID-19. ClinicalTrials.gov. Available at https://www.clinicaltrials.gov/ct2/show/NCT04362189. 2020 Aug 12; Accessed: September 11, 2020.
FDA approves study to investigate the use of cell therapy to treat COVID-19 related multisystem inflammatory syndrome in children (MIS-C). PR Newswire. 2020 Sep 16. Available at https://www.prnewswire.com/news-releases/fda-approves-study-to-investigate-the-use-of-cell-therapy-to-treat-covid-19-related-multisystem-inflammatory-syndrome-in-children-mis-c-301131904.html.
Extracellular vesicle infusion therapy for severe COVID-19 (EXIT COVID-19). ClinicalTrials.gov. Available at https://www.clinicaltrials.gov/ct2/show/NCT04493242. 2020 Jul 30; Accessed: October 19, 2020.
MediciNova announces opening of investigational new drug application for MN-166 (ibudilast) for prevention of acute respiratory distress syndrome in patients with COVID-19. MediciNova. 2020 Jul 01. Available at https://investors.medicinova.com/news-releases/news-release-details/medicinova-announces-opening-investigational-new-drug-1.
Safety and efficacy of NP-120 (ifenprodil) for the treatment of hospitalized patient with confirmed COVID-19 disease. ClinicalTrials.gov. Available at https://www.clinicaltrials.gov/ct2/show/NCT04382924. 2020 Dec 10; Accessed: May 14, 2020.
Eculizumab (Soliris) in Covid-19 Infected Patients (SOLID-C19). ClinicialTrials.gov. Available at https://clinicaltrials.gov/ct2/show/NCT04288713. 2020 Mar 30;
Alexion provides update on phase 3 study of Ultomiris (ravulizumab-cwvz) in hospitalized patients with severe COVID-19. Alexion Pharmaceuticals, Inc. 2021 Jan 13. Available at https://ir.alexion.com/news-releases/news-release-details/alexion-provides-update-phase-3-study-ultomirisr-ravulizumab.
Study to evaluate the safety and efficacy of ATYR1923 in patients with severe pneumonia related to COVID-19. ClinicalTrials.gov. Available at https://www.clinicaltrials.gov/ct2/show/NCT04412668. 2020 Jun 04;
Evaluation of Safety & Efficacy of BIO-11006 Inhalation Solution in Patients with ARDS. ClinicalTrials.gov. Available at https://www.clinicaltrials.gov/ct2/show/NCT03202394?term=NCT03202394&draw=2&rank=1. 2018 Dec 06; Accessed: Apr 24, 2020.
Chimerix Announces Initiation of a Phase 2/3 Study of DSTAT in Acute Lung Injury for Patients with Severe COVID-19. Chimerix. 2020 Apr 29. Available at https://ir.chimerix.com/news-releases/news-release-details/chimerix-announces-initiation-phase-23-study-dstat-acute-lung.
A study of opaganib in coronavirus disease 2019 pneumonia (COVID-19). ClinicalTrials.gov. Available at https://clinicaltrials.gov/ct2/show/NCT04414618. 2020 Jul 31;
Opaganib, a sphingosine kinase-2 (SK2) inhibitor in COVID-19 pneumonia. ClinicalTrials.gov. Available at https://clinicaltrials.gov/ct2/show/NCT04467840. 2020 Jul 17; Accessed: July 31, 2020.
LB1148 Now Available for Investigational Use to Treat Pulmonary Dysfunction Associated with COVID-19 Pneumonia. Leading BioSciences. 2020 May 15. Available at https://www.globenewswire.com/news-release/2020/05/15/2034269/0/en/Leading-BioSciences-Receives-IND-Clearance-for-Phase-2-COVID-19-Study.html.
Phase III DAS181 Lower Tract PIV Infection in Immunocompromised Subjects (Substudy: DAS181 for COVID-19): RCT Study. ClinicalTrials.gov. Available at https://clinicaltrials.gov/ct2/show/NCT03808922?term=DAS181&cond=COVID&draw=2&rank=4. 2020 Apr 17;
Applied Therapeutics Announces IND and Investigator-Initiated Studies of AT-001 in Critical COVID-19 Patients. Applied Therapeutics. 2020 Apr 02. Available at https://ir.appliedtherapeutics.com/news-releases/news-release-details/applied-therapeutics-announces-ind-and-investigator-initiated.
Miller J, Bruen C, Schnaus M, Zhang J, Ali S, Lind A, et al. Auxora versus standard of care for the treatment of severe or critical COVID-19 pneumonia: Results from a randomized controlled trial. Research Square. 2020 Jul 15. [Full Text].
Biohaven receives FDA may proceed letter to begin phase 2 trial of intranasal vazegepant to treat lung inflammation after COVID-19 infection. Biohaven Pharmaceuticals. 2020 Apr 09. Available at https://www.biohavenpharma.com/investors/news-events/press-releases/04-09-2020.
Evaluation of activity and safety of oral selinexor in participants with severe COVID-19 infection (coronavirus). ClinicalTrials.gov. Available at https://www.clinicaltrials.gov/ct2/show/NCT04349098. 2020 May 08; Accessed: October 7, 2020.
Evelo Biosciences, Rutgers University, and Robert Wood Johnson University Hospital Announce Submission of IND for a Phase 2 Study of EDP1815 in COVID-19 Patients. Evelo Biosciences. 2020 May 07. Available at https://ir.evelobio.com/news-releases/news-release-details/evelo-biosciences-rutgers-university-and-robert-wood-johnson.
Evelo Biosciences announces EDP1815 to advance into phase 2/3 TACTIC-E COVID-19 trial. Evelo Biosciences. 2020 Jun 22. Available at https://ir.evelobio.com/news-releases/news-release-details/evelo-biosciences-announces-edp1815-advance-phase-23-tactic-e.
VERU-111 suppresses key cytokines responsible for severe acute respiratory distress syndrome in COVID-19. Veru, Inc. 2020 Aug 04. Available at https://verupharma.com/news/veru-111-suppresses-key-cytokines-responsible-for-severe-acute-respiratory-distress-syndrome-in-covid-19/.
Q BioMed partner Mannin Research developing potential treatment for patients infected with coronavirus and other infectious diseases. Q BioMed. 2020 Feb 04. Available at https://qbiomed.com/news-and-media/news-2020/180-q-biomed-partner-mannin-research-developing-potential-treatment-for-patients-infected-with-coronavirus-and-other-infectious-diseases.
Diffusion Pharmaceuticals receives FDA guidance for international phase 1b/2b COVID-19 clinical program with TSC. Diffusion Pharmaceuticals. 2020 July 27. Available at https://investors.diffusionpharma.com/News/news-details/2020/Diffusion-Pharmaceuticals-Receives-FDA-Guidance-for-International-Phase-1b2b-COVID-19-Clinical-Program-with-TSC/default.aspx.
NCI drug Dictionary. Trans sodium crocetinate. NIH, National Cancer Institute. Available at https://www.cancer.gov/publications/dictionaries/cancer-drug/def/trans-sodium-crocetinate. Accessed: 2020 May 28.
FDA authorizes OPKO Health clinical trial evaluating Rayaldee in COVID-19 patients. OPKO Health. 2020 Jun 01. Available at https://www.opko.com/news-media/press-releases/detail/394/fda-authorizes-opko-health-clinical-trial-evaluating.
LYT-100 in Post-acute COVID-19 Respiratory Disease. ClinicalTrials.gov. Available at https://www.clinicaltrials.gov/ct2/show/NCT04652518. 2020 Dec 07; Accessed: December 11, 2020.
Ashvattha Therapeutics subsidiary Orpheris announces FDA agreement to initiate phase 2 study evaluating OP-101 in severe COVID-19 patients. Ashvattha Therapeutics. 2020 May 28. Available at https://avttx.com/ashvattha-therapeutics-subsidiary-orpheris-announces-fda-agreement-to-initiate-phase-2-study-evaluating-op-101-in-severe-covid-19-patients/.
A Study to Evaluate the Efficacy, Safety and Tolerability of IMU-838 as Addition to Investigator's Choice of Standard of Care Therapy, in Patients With Coronavirus Disease 19 (COVID-19). ClinicalTrials.gov. Available at https://www.clinicaltrials.gov/ct2/show/NCT04379271. 2020 May 11;
Immunic, Inc. announces first patients enrolled in investigator-sponsored phase 2 clinical trial of IMU-838 in combination with oseltamivir for the treatment of patients with moderate-to-severe COVID-19. Immunic, Inc. 2020 Jul 27. Available at https://www.immunic-therapeutics.com/2020/07/27/immunic-inc-announces-first-patients-enrolled-in-investigator-sponsored-phase-2-clinical-trial-of-imu-838-in-combination-with-oseltamivir-for-the-treatment-of-patients-with-moderate-to-severe-covid-19/.
Oryzon announces enrollment of first patient in ESCAPE: a Phase II clinical trial with vafidemstat in severely ill COVID-19 patients. Oryzon Genomics. 2020 May 18. Available at https://www.oryzon.com/sites/default/files/PRESS_RELEASE_13-2020.pdf.
Bhatt DL. First Human Trial of a Loading Dose of Icosapent Ethyl in Patients with COVID-19: Primary Results of the Vascepa COVID-19 CardioLink-9 Randomized Trial. Presented at the National Lipid Association Scientific Sessions December 12, 2020. [Full Text].
Prazosin to prevent COVID-19 (PREVENT-COVID Trial). ClinicalTrials.gov. Available at https://www.clinicaltrials.gov/ct2/show/NCT04365257. 2020 May 15; Accessed: June 16, 2020.
Konig MF, Powell M, Staedtke V, Bai RY, Thomas DL, Fischer N, et al. Preventing cytokine storm syndrome in COVID-19 using α-1 adrenergic receptor antagonists. J Clin Invest. 2020 May 26. [Medline]. [Full Text].
Study of Ampion for the treatment of adult COVID-19 patients requiring oxygen supplementation. ClinicalTrials.gov. Available at https://clinicaltrials.gov/ct2/show/NCT04456452. 2020 Jul 24;
Fulcrum Therapeutics Announces Initiation of Multi-Center Phase 3 (LOSVID) Trial with Losmapimod for Hospitalized COVID-19 Patients. Fulcrum Therapeutics. 2020 Jun 24. Available at https://ir.fulcrumtx.com/news-releases/news-release-details/fulcrum-therapeutics-announces-initiation-multi-center-phase-3.
Durect Corporation announces initiation of patient recruitment in phase 2 safety and efficacy study of DUR-928 in COVID-19 patients with acute liver or kidney injury. Durect Corporation. 2020 Jul 01. Available at https://investors.durect.com/news-releases/news-release-details/durect-corporation-announces-initiation-patient-recruitment?field_nir_news_date_value[min]=2020.
Aclaris Therapeutics Supports Investigator-Initiated Clinical Trial of ATI-450 for Cytokine Release Syndrome in Hospitalized Patients with COVID-19. Aclaris Therapeutics. 2020 Jun 17. Available at https://investor.aclaristx.com/news-releases/news-release-details/aclaris-therapeutics-supports-investigator-initiated-clinical.
Study to evaluate the efficacy and safety of leronlimab for mild to moderate COVID-19. ClinicalTrials.gov. Available at https://www.clinicaltrials.gov/ct2/show/NCT04343651. 2020 Jun 11; Accessed: July 13, 2020.
Study to evaluate the efficacy and safety of leronlimab for patients with severe or critical coronavirus disease 2019 (COVID-19). ClinicalTrials.gov. Available at https://www.clinicaltrials.gov/ct2/show/NCT04347239. 2020 Jun 11; Accessed: July 13, 2020.
Biophytis receives FDA IND clearance for COVA, a phase 2/3 clinical trial with sarconeos (BIO101) for the treatment of patients with COVID-19 related respiratory failure. Biophytis. 2020 Jul 01. Available at https://www.biophytis.com/wp-content/uploads/2020/07/Biophytis-COVA-FDA-IND-Clearance-PR-EN-vF-.pdf.
FDA clears abivertinib for Phase 2 safety and efficacy study in hospitalized patients with moderate to severe COVID-19. Sorrento Therapeutics. 2020 July 20. Available at https://investors.sorrentotherapeutics.com/news-releases/news-release-details/fda-clears-abivertinib-phase-2-safety-and-efficacy-study.
Safety, tolerability and efficacy of nangibotide in mechanically ventilated patients with COVID-19 and features of systemic inflammation. ClinicalTrials.gov. Available at https://www.clinicaltrials.gov/ct2/show/NCT04429334. 2020 Jun 12; Accessed: July 23, 2020.
Can-Fite Submits Investigational New Drug Application to U.S. FDA for COVID-19 Phase II Study. Can-Fite BioPharma. 2020 Jul 27. Available at https://ir.canfite.com/press-releases/detail/917/can-fite-submits-investigational-new-drug-application-to-u-s-fda-for-covid-19-phase-ii-study.
LSALT peptide vs placebo to prevent ARDS and acute kidney injury in patients infected with SARS-CoV-2 (COVID-19). ClinicalTrials.gov. Available at https://www.clinicaltrials.gov/ct2/show/NCT04402957. 2020 Jun 16; Accessed: : July 28, 2020.
ReAlta Life Sciences announces U.S. FDA clearance of first investigational new drug application for RLS-0071. ReAlta Life Sciences. 2020 Jul 28. Available at https://realtalifesciences.com/realta-life-sciences-announces-u-s-fda-clearance-of-first-investigational-new-drug-application-for-rls-0071/.
Safety and antiviral activity of BLD-2660 in COVID-19 hospitalized subjects. ClinicalTrials.gov. Available at https://clinicaltrials.gov/ct2/show/NCT04334460. 2020 Sep 03; Accessed: September 15, 2020.
Enzychem Lifesciences announces FDA acceptance of phase 2 study of EC-18 in preventing acute respiratory distress Syndrome (ARDS) due to COVID-19 pneumonia. Enzychem Lifesciences. 2020 Aug 14. Available at https://www.enzychem.com/enzychem-lifesciences-announces-fda-acceptance-of-phase-2-study-of-ec-18-in-preventing-acute-respiratory-distress-syndrome-ards-due-to-covid-19-pneumonia/.
A study of cell therapy in COVID-19 subjects with acute kidney injury who are receiving renal replacement therapy. ClinicalTrials.gov. Available at https://clinicaltrials.gov/ct2/show/NCT04445220. 2020 Aug 13; Accessed: August 19, 2020.
BCG Vaccine for Health Care Workers as Defense Against COVID 19 (BADAS). ClinicalTrials.gov. Available at https://clinicaltrials.gov/ct2/show/NCT04348370. 2020 May 27; Accessed: August 19, 2020.
Synthetic cannabinoid drug for COVID-19 approved for phase 1 clinical trials. Forbes. 2020 Aug 20. Available at https://www.forbes.com/sites/emilyearlenbaugh/2020/08/20/synthetic-cannabinoid-drug-for-covid-19-approved-for-phase-1-clinical-trials/#7b9374223329.
Intravenous infusion of CAP-1002 in patients with COVID-19 (INSPIRE). ClinicalTrials.gov. Available at https://www.clinicaltrials.gov/ct2/show/NCT04623671. 2020 Nov 24; Accessed: November 25, 2020.
Study of LAU-7b for the treatment of COVID-19 disease in adults (RESOLUTION). ClinicalTrials.gov. Available at https://www.clinicaltrials.gov/ct2/show/NCT04417257. 2020 Jul 17; Accessed: August 26, 2020.
SPI-1005 treatment in severe COVID-19 patients. ClinicalTrials.gov. Available at https://www.clinicaltrials.gov/ct2/show/NCT04483973. 2020 Jul 23; Accessed: September 14, 2020.
Rigel Announces NIH/NHLBI-sponsored trial of fostamatinib in hospitalized COVID-19 patients in collaboration with Inova. Rigel Pharmaceuticals. 2020 Sep 17. Available at https://ir.rigel.com/news-events/press-releases/detail/296/rigel-announces-nihnhlbi-sponsored-trial-of-fostamatinib.
Vadadustat for the prevention and treatment of acute respiratory distress syndrome (ARDS) in hospitalized patients with coronavirus disease 2019 (COVID-19). ClinicalTrials.gov. Available at https://www.clinicaltrials.gov/ct2/show/NCT04478071. 2020 Sep 10; Accessed: September 22, 2020.
FSD Pharma begins Phase 2 clinical trial to evaluate FSD201 for the treatment of hospitalized COVID-19 patients. FSD Pharma Inc. 2020 Sep 28. Available at https://www.fsdpharma.com/news/fsd-pharma-begins-phase-2-clinical-trial-to-evaluate-fsd201-for-the-treatment-of-hospitalized-covid-19-patients/.
A randomized, double-blind, placebo-controlled study to evaluate the safety and efficacy of EB05 + SOC vs. placebo + SOC in adult hospitalized patients with moderate to severe COVID-19. ClinicalTrials.gov. Available at https://www.clinicaltrials.gov/ct2/show/NCT04401475. 2020 Jul 01; Accessed: October 26, 2020.
Lenze EJ, Mattar C, Zorumski CF, Stevens A, Schweiger J, Nicol GE, et al. Fluvoxamine vs Placebo and Clinical Deterioration in Outpatients With Symptomatic COVID-19: A Randomized Clinical Trial. JAMA. 2020 Nov 12. [Medline]. [Full Text].
COVID R&D Alliance launches trial of Amgen, UCB, Takeda drugs. Reuters. 2020 Nov 30. Available at https://www.reuters.com/article/health-coronavirus-treatment-trial/covid-rd-alliance-launches-trial-of-amgen-ucb-takeda-drugs-idUSL1N2I31W4.
Hepion Pharmaceuticals announces FDA clearance of IND application for CRV431 for COVID-19. Hepion Pharmaceuticals. 2020 Dec 22. Available at https://hepionpharma.com/news/hepion-pharmaceuticals-announces-fda-clearance-of-ind-application-for-crv431-for-covi/4573734.
Study of ensifentrine or placebo delivered via pMDI in hospitalized patients with COVID-19. ClinicalTrials.gov. Available at https://www.clinicaltrials.gov/ct2/show/NCT04527471. 2020 Dec 14; Accessed: January 14, 2021.
Tiziana Life Sciences Announces an Expedited Clinical Development Plan for Its Anti-Interleukin-6-Receptor, a Fully Human Monoclonal Antibody, for the Treatment of COVID-19 Patients. Tiziana Life Sciences. 2021 Aug 04. Available at https://ir.tizianalifesciences.com/news-releases/news-release-details/tiziana-life-sci-plc-expedited-clinical-development-plan.
Gilham D, Smith AL, Fu L, Moore DY, Muralidharan A, Reid PM. Bromodomain and extraterminal protein inhibitor, apabetalone (RVX-208), reduces ACE2 expression and attenuates SARS-CoV-2 infection in vitro. bioRxiv. 2021 Mar 11. [Full Text].
Bucillamine in treatment of patients with COVID-19. ClinicalTrials.gov. Available at https://clinicaltrials.gov/ct2/show/NCT04504734. 2020 Aug 07; Accessed: August 7, 2020.
CD24Fc as a nonantiviral immunomodulator in COVID-19 treatment (SAC-COVID). ClinicalTrials.gov. Available at https://clinicaltrials.gov/ct2/show/NCT04317040. 2020 Apr 10;
Gottlieb RL, Nirula A, Chen P, Boscia J, Heller B, Morris J, et al. Effect of Bamlanivimab as Monotherapy or in Combination With Etesevimab on Viral Load in Patients With Mild to Moderate COVID-19: A Randomized Clinical Trial. JAMA. 2021 Jan 21. [Medline]. [Full Text].
FDA. Fact sheet for health care providers emergency use authorization (EUA) of casirivimab and imdevimab. United States Food and Drug Administration. Available at https://www.fda.gov/media/143892/download. 2020 Nov 21; Accessed: November 21, 2020.
Weinreich DM, Sivapalasingam S, Norton T, Ali S, Gao H, Bhore R, et al. REGN-COV2, a Neutralizing Antibody Cocktail, in Outpatients with Covid-19. N Engl J Med. 2020 Dec 17. [Medline]. [Full Text].
Regeneron’s COVID-19 outpatient trial prospectively demonstrates that REGN-COV2 antibody cocktail significantly reduced virus levels and need for further medical attention. Regeneron. 2020 Oct 28. Available at https://investor.regeneron.com/news-releases/news-release-details/regenerons-covid-19-outpatient-trial-prospectively-demonstrates.
Phase 3 trial shows REGEN-COV (casirivimab with imdevimab) antibody cocktail reduced hospitalization or death by 70% in non-hospitalized COVID-19 patients. Regeneron. 2021 Mar 23. Available at https://investor.regeneron.com/news-releases/news-release-details/phase-3-trial-shows-regen-covtm-casirivimab-imdevimab-antibody.
Safety, tolerability, and efficacy of anti-spike (S) SARS-CoV-2 monoclonal antibodies for hospitalized adult patients with COVID-19. ClinicalTrials.gov. Available at https://clinicaltrials.gov/ct2/show/NCT04426695. 2020 Oct 01; Accessed: October 2, 2020.
Regeneron announces encouraging initial data from COVID-19 antibody cocktail trial in hospitalized patients on low-flow oxygen. PRNewswire. 2020 Dec 29. Available at https://investor.regeneron.com/news-releases/news-release-details/regeneron-announces-encouraging-initial-data-covid-19-antibody.
Phase 3 prevention trial showed 81% reduced risk of symptomatic SARS-CoV-2 infections with subcutaneous administration of REGEN-COV (casirivimab with imdevimab). Regeneron. 20221 Apr 12. Available at https://investor.regeneron.com/news-releases/news-release-details/phase-3-prevention-trial-showed-81-reduced-risk-symptomatic-sars.
Cathcart AL, Havenar-Daughton C, Lempp FA, Ma D, Schmid M, Agostini ML, et al. The dual function monoclonal antibodies VIR-7831 and VIR-7832 demonstrate potent in vitro and in vivo activity against SARS-CoV-2. bioRxiv. 2021 Mar 10. [Full Text].
GSK and Vir Biotechnology announce submission of emergency use authorization request to FDA for VIR-7831 for the early treatment of COVID-19. VIR Biotechnology. 2021 Mar 26. Available at https://investors.vir.bio/news-releases/news-release-details/gsk-and-vir-biotechnology-announce-submission-emergency-use.
Lilly, VIR Biotechnology and GSK announce positive topline data from the phase 2 BLAZE-4 trial evaluating bamlanivimab with VIR-7831 in low-risk adults with COVID-19. VIR Biotechnology. 2021 Mar 29. [Full Text].
Lurie N, Saville M, Hatchett R, Halton J. Developing Covid-19 Vaccines at Pandemic Speed. N Engl J Med. 2020 May 21. 382 (21):1969-1973. [Medline]. [Full Text].
Koirala A, Joo YJ, Khatami A, Chiu C, Britton PN. Vaccines for COVID-19: The current state of play. Paediatr Respir Rev. 2020 Sep. 35:43-49. [Medline]. [Full Text].
Iba T, Levy JH, Levi M, Connors JM, Thachil J. Coagulopathy of Coronavirus Disease 2019. Crit Care Med. 2020 Sep. 48 (9):1358-1364. [Medline]. [Full Text].
Katneni UK, Alexaki A, Hunt RC, Schiller T, DiCuccio M, Buehler PW, et al. Coagulopathy and Thrombosis as a Result of Severe COVID-19 Infection: A Microvascular Focus. Thromb Haemost. 2020 Aug 24. [Medline]. [Full Text].
Ferguson J, Volk S, Vondracek T, Flanigan J, Chernaik A. Empiric therapeutic anticoagulation and mortality in critically ill patients with respiratory failure from SARS-CoV-2: A retrospective cohort study. J Clin Pharmacol. 2020 Sep 3. [Medline]. [Full Text].
Paranjpe I, Fuster V, Lala A, Russak AJ, Glicksberg BS, Levin MA, et al. Association of Treatment Dose Anticoagulation With In-Hospital Survival Among Hospitalized Patients With COVID-19. J Am Coll Cardiol. 2020 Jul 7. 76 (1):122-124. [Medline]. [Full Text].
Assessing Safety, Hospitalization and Efficacy of rNAPc2 in COVID-19 (ASPEN). ClinicalTrials.gov. Available at https://www.clinicaltrials.gov/ct2/show/NCT04655586. 2020 Dec 15; Accessed: December 16, 2020.
Zhou P, Yang XL, Wang XG, Hu B, Zhang L, Zhang W, et al. A pneumonia outbreak associated with a new coronavirus of probable bat origin. Nature. 2020 Mar. 579 (7798):270-273. [Medline]. [Full Text].
Lopes RD, Macedo AVS, de Barros E Silva PGM, Moll-Bernardes RJ, Feldman A, D'Andréa Saba Arruda G, et al. Continuing versus suspending angiotensin-converting enzyme inhibitors and angiotensin receptor blockers: Impact on adverse outcomes in hospitalized patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)--The BRACE CORONA Trial. Am Heart J. 2020 Aug. 226:49-59. [Medline]. [Full Text].
Clerkin KJ, Fried JA, Raikhelkar J, Sayer G, Griffin JM, Masoumi A, et al. Coronavirus Disease 2019 (COVID-19) and Cardiovascular Disease. Circulation. 2020 Mar 21. [Medline]. [Full Text].
Fang L, Karakiulakis G, Roth M. Correction to Lancet Respir Med 2020; 8: e21. Lancet Respir Med. 2020 Jun. 8 (6):e54. [Medline]. [Full Text].
Kuba K, Imai Y, Rao S, Gao H, Guo F, Guan B, et al. A crucial role of angiotensin converting enzyme 2 (ACE2) in SARS coronavirus-induced lung injury. Nat Med. 2005 Aug. 11 (8):875-9. [Medline]. [Full Text].
Vaduganathan M, Vardeny O, Michel T, McMurray JJV, Pfeffer MA, Solomon S. Renin–Angiotensin–Aldosterone System Inhibitors in Patients with Covid-19. N Engl J Med. 2020 March 30. [Medline]. [Full Text].
Ishiyama Y, Gallagher PE, Averill DB, Tallant EA, Brosnihan KB, Ferrario CM. Upregulation of angiotensin-converting enzyme 2 after myocardial infarction by blockade of angiotensin II receptors. Hypertension. 2004 May. 43 (5):970-6. [Medline]. [Full Text].
Ferrario CM, Jessup J, Chappell MC, Averill DB, Brosnihan KB, Tallant EA, et al. Effect of angiotensin-converting enzyme inhibition and angiotensin II receptor blockers on cardiac angiotensin-converting enzyme 2. Circulation. 2005 May 24. 111 (20):2605-10. [Medline]. [Full Text].
Klimas J, Olvedy M, Ochodnicka-Mackovicova K, Kruzliak P, Cacanyiova S, Kristek F, et al. Perinatally administered losartan augments renal ACE2 expression but not cardiac or renal Mas receptor in spontaneously hypertensive rats. J Cell Mol Med. 2015 Aug. 19 (8):1965-74. [Medline]. [Full Text].
Walters TE, Kalman JM, Patel SK, Mearns M, Velkoska E, Burrell LM. Angiotensin converting enzyme 2 activity and human atrial fibrillation: increased plasma angiotensin converting enzyme 2 activity is associated with atrial fibrillation and more advanced left atrial structural remodelling. Europace. 2017 Aug 1. 19 (8):1280-1287. [Medline]. [Full Text].
Burchill LJ, Velkoska E, Dean RG, Griggs K, Patel SK, Burrell LM. Combination renin-angiotensin system blockade and angiotensin-converting enzyme 2 in experimental myocardial infarction: implications for future therapeutic directions. Clin Sci (Lond). 2012 Dec. 123 (11):649-58. [Medline].
Bozkurt B, Kovacs R, Harrington B. Joint HFSA/ACC/AHA Statement Addresses Concerns Re: Using RAAS Antagonists in COVID-19. J Card Fail. 2020 May. 26 (5):370. [Medline]. [Full Text].
Sama IE, Ravera A, Santema BT, van Goor H, Ter Maaten JM, Cleland JGF, et al. Circulating plasma concentrations of angiotensin-converting enzyme 2 in men and women with heart failure and effects of renin-angiotensin-aldosterone inhibitors. Eur Heart J. 2020 May 14. 41 (19):1810-1817. [Medline]. [Full Text].
Baral R, Tsampasian V, Debski M, Moran B, Garg P, Clark A, et al. Association Between Renin-Angiotensin-Aldosterone System Inhibitors and Clinical Outcomes in Patients With COVID-19: A Systematic Review and Meta-analysis. JAMA Netw Open. 2021 Mar 1. 4 (3):e213594. [Medline]. [Full Text].
Torres A, Blasi F, Dartois N, Akova M. Which individuals are at increased risk of pneumococcal disease and why? Impact of COPD, asthma, smoking, diabetes, and/or chronic heart disease on community-acquired pneumonia and invasive pneumococcal disease. Thorax. 2015 Oct. 70 (10):984-9. [Medline]. [Full Text].
Drucker DJ. Coronavirus infections and type 2 diabetes-shared pathways with therapeutic implications. Endocr Rev. 2020 Apr 15. [Medline]. [Full Text].
Muniyappa R, Gubbi S. COVID-19 Pandemic, Corona Viruses, and Diabetes Mellitus. Am J Physiol Endocrinol Metab. 2020 Mar 31. [Medline]. [Full Text].
DPP4 dipeptidyl peptidase 4. National Center for Biotechnology Information (NCBI). Available at https://www.ncbi.nlm.nih.gov/gene/1803. 2020 Apr 20; Accessed: 2020 Apr 21.
FDA. Coronavirus (COVID-19) Update: FDA Revokes Emergency Use Authorization for Chloroquine and Hydroxychloroquine. US Food and Drug Administration. 2020 Jun 15. Available at https://www.fda.gov/news-events/press-announcements/coronavirus-covid-19-update-fda-revokes-emergency-use-authorization-chloroquine-and.
NIH Media Advisory. NIH halts clinical trial of hydroxychloroquine. National Institutes of Health. 2020 Jun 20. Available at https://www.nih.gov/news-events/news-releases/nih-halts-clinical-trial-hydroxychloroquine.
Wang M, Cao R, Zhang L, Yang X, Liu J, Xu M, et al. Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro. Cell Res. 2020 Feb 4. [Medline].
Yao X, Ye F, Zhang M, Cui C, Huang B, Niu P, et al. In Vitro Antiviral Activity and Projection of Optimized Dosing Design of Hydroxychloroquine for the Treatment of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). Clin Infect Dis. 2020 Mar 9. [Medline].
Gautret P, Lagier JC, Parola P, Hoang VT, Meddeb L, Mailhe M, et al. Hydroxychloroquine and azithromycin as a treatment of COVID-19: results of an open-label non-randomized clinical trial International Journal of Antimicrobial Agents (2020) (prepublication).
Gautret P, Lagier JC, Parola P, Hoang VT, Meddeb, Sevestre J, et al. Hydroxychloroquine-Azithromycin and COVID-19. Available at https://www.mediterranee-infection.com/wp-content/uploads/2020/03/COVID-IHU-2-1.pdf. 2020 Mar 30;
Molina JM, Delaugerre C, Goff JL, Mela-Lima B, Ponscarme D, Goldwirt L, et al. No Evidence of Rapid Antiviral Clearance or Clinical Benefit with the Combination of Hydroxychloroquine and Azithromycin in Patients with Severe COVID-19 Infection. Med Mal Infect. 2020 Mar 30. [Medline]. [Full Text].
Skipper CP, Pastick KA, Engen NW, Bangdiwala AS, Abassi M, Lofgren SM, et al. Hydroxychloroquine in Nonhospitalized Adults With Early COVID-19: A Randomized Trial. Ann Intern Med. 2020 Jul 16. [Medline]. [Full Text].
NIH begins clinical trial of hydroxychloroquine and azithromycin to treat COVID-19. National Institutes of Health. Available at https://www.nih.gov/news-events/news-releases/nih-begins-clinical-trial-hydroxychloroquine-azithromycin-treat-covid-19. 2020 May 14;
A5395: A randomized, double-blind, placebo-controlled trial to evaluate the efficacy of hydroxychloroquine and azithromycin to prevent hospitalization or death in persons with COVID-19. AIDS Clinical Trials Group. Available at https://actgnetwork.org/studies/a5395/. Accessed: 2020 May 15.
Abella, BS, Jolkovsky EL, Biney BT, and the Prevention and Treatment of COVID-19 With Hydroxychloroquine (PATCH) Investigators. Efficacy and safety of hydroxychloroquine vs placebo for pre-exposure SARS-CoV-2 prophylaxis among health care workers – A randomized clinical trial. JAMA Int Med. 2020 Sep 30. [Full Text].
Hydroxychloroquine Post Exposure Prophylaxis for Coronavirus Disease (COVID-19) NCT04318444. ClinicalTrials.gov. Available at https://www.clinicaltrials.gov/ct2/show/NCT04318444. 2020 Apr 27;
Hydroxychloroquine as Prophylaxis for COVID-19 in Healthcare Workers (HCQPreP) NCT04363450. ClinicalTrials.gov. Available at https://www.clinicaltrials.gov/ct2/show/NCT04363450. 2020 Apr 29;
Healthcare Worker Exposure Response and Outcomes of Hydroxychloroquine (HERO-HCQ) NCT04334148. ClinicalTrials.gov. 2020 May 14. Available at https://clinicaltrials.gov/ct2/show/NCT04334148.
Rajasingham R, Bangdiwala AS, Nicol MR, Skipper CP, Pastick KA, Axelrod ML, et al. Hydroxychloroquine as pre-exposure prophylaxis for COVID-19 in healthcare workers: a randomized trial. Clin Infect Dis. 2020 Oct 17. [Medline]. [Full Text].
Boulware DR, Pullen MF, Bangdiwala AS, Pastick KA, Lofgren SM, Okafor EC, et al. A Randomized Trial of Hydroxychloroquine as Postexposure Prophylaxis for Covid-19. N Engl J Med. 2020 Jun 3. [Medline]. [Full Text].
Ray WA, Murray KT, Hall K, Arbogast PG, Stein CM. Azithromycin and the risk of cardiovascular death. N Engl J Med. 2012 May 17. 366 (20):1881-90. [Medline]. [Full Text].
Simpson TF, Kovacs RJ, Stecker EC. Ventricular Arrhythmia Risk Due to Hydroxychloroquine-Azithromycin Treatment For COVID-19. American College of Cardiology; Cardiology Magazine. Available at https://www.acc.org/latest-in-cardiology/articles/2020/03/27/14/00/ventricular-arrhythmia-risk-due-to-hydroxychloroquine-azithromycin-treatment-for-covid-19. 2020 Mar 29; Accessed: April 1, 2020.
[Guideline] Roden DM, Harrington RA, Poppas A, Russo AM. Considerations for Drug Interactions on QTc in Exploratory COVID-19 (Coronavirus Disease 2019) Treatment. Circulation. 2020 Apr 8. [Medline]. [Full Text].
Borba M, de Almeida Val F, Sampaio VS, Alexandre MA, Melo GC, Brito M, et al. Chloroquine diphosphate in two different dosages as adjunctive therapy of hospitalized patients with severe respiratory syndrome in the context of coronavirus (SARS-CoV-2) infection: Preliminary safety results of a randomized, double-blinded, phase IIb clinical trial (CloroCovid-19 Study). MedRxiv. 2020 Apr 11. [Full Text].
Lane JCE, Weaver J, Kostka K, Duarte-Salles T, Abrahao MTF, Alghoul H, et al. Safety of hydroxychloroquine, alone and in combination with azithromycin, in light of rapid wide-spread use for COVID-19: a multinational, network cohort and self-controlled case series study. medRxiv. 2020 Apr 10. [Full Text].
[Guideline] NIH. Potential Antiviral Drugs Under Evaluation for the treatment of COVID-19. COVID-19 Treatment Guidelines. Available at https://www.covid19treatmentguidelines.nih.gov/antiviral-therapy/. 2020 Jun 11; Accessed: June 16, 2020.
RECOVERY Collaborative Group. Lopinavir-ritonavir in patients admitted to hospital with COVID-19 (RECOVERY): a randomized, controlled, open-label, platform trial. The Lancet. 2020 Oct 05. [Full Text].
Cao B, Wang Y, Wen D, Liu W, Wang J, Fan G, et al. A Trial of Lopinavir-Ritonavir in Adults Hospitalized with Severe Covid-19. N Engl J Med. 2020 Mar 18. [Medline]. [Full Text].
Baden LR, Rubin EJ. Covid-19 - The Search for Effective Therapy. N Engl J Med. 2020 Mar 18. [Medline]. [Full Text].
Li Y, Xie Z, Lin W, Cai W, Wen C, Guan Y, et al. Efficacy and safety of lopinavir/ritonavir or Arbidol in adult patients with mild/moderate COVID-19: an exploratory randomized controlled trial. Med (from Cell Press). 2020 Apr 17. [Full Text].
Hung IFN, Lung KC, Tso EYK, Liu R, Chung TWH, Chu MY, et al. Triple combination of interferon beta-1b, lopinavir–ritonavir, and ribavirin in the treatment of patients admitted to hospital with COVID-19: an open-label, randomised, phase 2 trial. Lancet. 2020 May 08. [Full Text].
Momekov G, Momekova D. Ivermectin as a potential COVID-19 treatment from the pharmacokinetic point of view: antiviral levels are not likely attainable with known dosing regimens. Biotechnology & Biotechnological Equipment. 2020. 2020. 34(1):469-74. [Full Text].
Chaccour C, Hammann F, Ramón-García S, Rabinovich NR. Ivermectin and Novel Coronavirus Disease (COVID-19): Keeping Rigor in Times of Urgency. Am J Trop Med Hyg. 2020 Apr 16. [Medline]. [Full Text].
López-Medina E, López P, Hurtado IC, Dávalos DM, Ramirez O, Martínez E, et al. Effect of Ivermectin on Time to Resolution of Symptoms Among Adults With Mild COVID-19: A Randomized Clinical Trial. JAMA. 2021 Apr 13. 325 (14):1426-1435. [Medline]. [Full Text].
ViralClear halts its phase 2 hospitalized COVID-19 trial. BioSig Technologies. 2020 Oct 26. Available at https://www.biosig.com/news-media/press-releases/detail/234/viralclear-halts-its-phase-2-hospitalized-covid-19-trial.
Update on CALAVI phase II trials for Calquence in patients hospitalized with respiratory symptoms of COVID-19. AstraZeneca. 2020 Nov 12. Available at https://www.astrazeneca.com/content/astraz/media-centre/press-releases/2020/update-on-calavi-phase-ii-trials-for-calquence-in-patients-hospitalised-with-respiratory-symptoms-of-covid-19.html.
Incyte Announces Results of Phase 3 RUXCOVID Study of Ruxolitinib (Jakafi) as a Treatment for Patients with COVID-19 Associated Cytokine Storm. Incyte Corp. 2020 Dec 14. [Full Text].
Lian N, Xie H, Lin S, Huang J, Zhao J, Lin Q. Umifenovir treatment is not associated with improved outcomes in patients with coronavirus disease 2019: a retrospective study. Clin Microbiol Infect. 2020 Jul. 26 (7):917-921. [Medline]. [Full Text].
[Guideline] Giudicessi JR, Noseworthy PA, Friedman PA, Ackerman MJ. Urgent guidance for navigating and circumventing the QTc prolonging and torsadogenic potential of possible pharmacotherapies for COVID-19. Mayo Clin Proc. 2020 Apr 07. [Full Text].
Mercuro NJ, Yen CF, Shim DJ, Maher TR, McCoy CM, Zimetbaum PJ, et al. Risk of QT Interval Prolongation Associated With Use of Hydroxychloroquine With or Without Concomitant Azithromycin Among Hospitalized Patients Testing Positive for Coronavirus Disease 2019 (COVID-19). JAMA Cardiol. 2020 May 1. [Medline]. [Full Text].
Chorin E, Dai M, Shulman E, Wadhwani L, et al. The QT Interval in Patients with SARS-CoV-2 Infection Treated with Hydroxychloroquine/Azithromycin. medRxiv. 2020 Apr 03. [Full Text].
FDA Combating COVID-19 with Medical Devices. US Food and Drug Administration. Available at https://www.fda.gov/media/136702/download. 2020 Jun 15; Accessed: June 19, 2020.
Zhang Q, et al. Cellular nanosponges inhibit SARS-CoV-2 infectivity. Nano Lett. 2020 Jun 17. [Medline]. [Full Text].
[Guideline] Centers for Disease Control and Prevention. Coronavirus Disease 2019 (COVID-19): Evaluating and Testing PUI. Centers for Disease Control and Prevention. Available at https://www.cdc.gov/coronavirus/2019-ncov/hcp/clinical-criteria.html. March 9, 2020; Accessed: March 18, 2020.
[Guideline] Centers for Disease Control and Prevention. Interim guidelines for collecting, handling, and testing clinical specimens from persons for coronavirus disease 2019 (COVID-19). CDC. Available at https://www.cdc.gov/coronavirus/2019-nCoV/lab/guidelines-clinical-specimens.html. 2020 Nov 05; Accessed: November 16, 2020.
[Guideline] Center for Clinical Standards and Quality/Quality, Safety & Oversight Group. Guidance for Infection Control and Prevention Concerning Coronavirus Disease (COVID-19): FAQs and Considerations for Patient Triage, Placement and Hospital Discharge. Available at https://www.cms.gov/files/document/qso-20-13-hospitalspdf.pdf-2. March 4, 2020; Accessed: March 4, 2020.
Puopolo KM, Hudak ML, Kimberlin DW, Cummings J. Management of Infants Born to Mothers with COVID-19. American Academy of Pediatrics. Available at https://downloads.aap.org/AAP/PDF/COVID%2019%20Initial%20Newborn%20Guidance.pdf. April 2, 2020; Accessed: April 3, 2020.
[Guideline] AAP. FAQs: Management of Infants Born to Mothers with Suspected or Confirmed COVID-19. American Academy of Pediatrics. Available at https://services.aap.org/en/pages/2019-novel-coronavirus-covid-19-infections/faqs-management-of-infants-born-to-covid-19-mothers/. May 21, 2020; Accessed: May 27, 2020.
[Guideline] COVID-19 Treatment Guidelines Panel. Coronavirus Disease 2019 (COVID-19) Treatment Guidelines. National Institutes of Health. Available at https://www.covid19treatmentguidelines.nih.gov/. 2021 Mar 05; Accessed: March 12, 2021.
[Guideline] Moores LK, Tritschler T, Brosnahan S, Carrier M, Collen JF, Doerschug K, et al. Prevention, diagnosis and treatment of venous thromboembolism in patients with COVID-19: CHEST Guideline and Expert Panel Report. Chest. 2020 Jun 2. [Medline]. [Full Text].
[Guideline] Thachil J, Tang N, Gando S, Falanga A, Cattaneo M, Levi M, et al. ISTH interim guidance on recognition and management of coagulopathy in COVID-19. J Thromb Haemost. 2020 May. 18 (5):1023-1026. [Medline]. [Full Text].
[Guideline] COVID-19 Treatment Guidelines Panel. Antithrombotic Therapy in Patients with COVID-19. National Institutes of Health. Available at https://www.covid19treatmentguidelines.nih.gov/antithrombotic-therapy/. 2020 May 12; Accessed: June 19, 2020.

Media Gallery

The heart is normal in size. There are diffuse, patchy opacities throughout both lungs, which may represent multifocal viral/bacterial pneumonia versus pulmonary edema. These opacities are particularly confluent along the periphery of the right lung. There is left midlung platelike atelectasis. Obscuration of the left costophrenic angle may represent consolidation versus a pleural effusion with atelectasis. There is no pneumothorax.
The heart is normal in size. There are bilateral hazy opacities, with lower lobe predominance. These findings are consistent with multifocal/viral pneumonia. No pleural effusion or pneumothorax are seen.
The heart is normal in size. Patchy opacities are seen throughout the lung fields. Patchy areas of consolidation at the right lung base partially silhouettes the right diaphragm. There is no effusion or pneumothorax. Degenerative changes of the thoracic spine are noted.
The same patient as above 10 days later.
The trachea is in midline. The cardiomediastinal silhouette is normal in size. There are diffuse hazy reticulonodular opacities in both lungs. Differential diagnoses include viral pneumonia, multifocal bacterial pneumonia or ARDS. There is no pleural effusion or pneumothorax.
Axial chest CT demonstrates patchy ground-glass opacities with peripheral distribution.
Coronal reconstruction chest CT of the same patient above, showing patchy ground-glass opacities.
Axial chest CT shows bilateral patchy consolidations (arrows), some with peripheral ground-glass opacity. Findings are in peripheral and subpleural distribution.

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Author

David J Cennimo, MD, FAAP, FACP, FIDSA, AAHIVS Associate Professor of Medicine and Pediatrics, Adult and Pediatric Infectious Diseases, Rutgers New Jersey Medical School

David J Cennimo, MD, FAAP, FACP, FIDSA, AAHIVS is a member of the following medical societies: American Academy of HIV Medicine, American Academy of Pediatrics, American College of Physicians, American Medical Association, HIV Medicine Association, Infectious Diseases Society of America, Medical Society of New Jersey, Pediatric Infectious Diseases Society

Disclosure: Nothing to disclose.

Coauthor(s)

Scott J Bergman, PharmD, FCCP, FIDSA, BCPS, BCIDP Antimicrobial Stewardship Program Coordinator, Infectious Diseases Pharmacy Residency Program Director, Department of Pharmaceutical and Nutrition Care, Division of Infectious Diseases, Nebraska Medicine; Clinical Associate Professor, Department of Pharmacy Practice, College of Pharmacy, University of Nebraska Medical Center

Scott J Bergman, PharmD, FCCP, FIDSA, BCPS, BCIDP is a member of the following medical societies: American Association of Colleges of Pharmacy, American College of Clinical Pharmacy, American Pharmacists Association, American Society for Microbiology, American Society of Health-System Pharmacists, Infectious Diseases Society of America, Society of Infectious Diseases Pharmacists

Disclosure: Received research grant from: Merck & Co., Inc.

Keith M Olsen, PharmD, FCCP, FCCM Dean and Professor, College of Pharmacy, University of Nebraska Medical Center

Disclosure: Nothing to disclose.

Specialty Editor Board

Mary L Windle, PharmD Adjunct Associate Professor, University of Nebraska Medical Center College of Pharmacy; Editor-in-Chief, Medscape Drug Reference

Disclosure: Nothing to disclose.

Chief Editor

Michael Stuart Bronze, MD David Ross Boyd Professor and Chairman, Department of Medicine, Stewart G Wolf Endowed Chair in Internal Medicine, Department of Medicine, University of Oklahoma Health Science Center; Master of the American College of Physicians; Fellow, Infectious Diseases Society of America; Fellow of the Royal College of Physicians, London

Michael Stuart Bronze, MD is a member of the following medical societies: Alpha Omega Alpha, American College of Physicians, American Medical Association, Association of Professors of Medicine, Infectious Diseases Society of America, Oklahoma State Medical Association, Southern Society for Clinical Investigation

Disclosure: Nothing to disclose.

Additional Contributors

Molly Marie Miller, PharmD Pharmacy Resident, Nebraska Medicine

Molly Marie Miller, PharmD is a member of the following medical societies: American College of Clinical Pharmacy, American Pharmacists Association, American Society of Health-System Pharmacists, Nebraska Pharmacists Association, Society of Infectious Diseases Pharmacists

Disclosure: Nothing to disclose.

Which medications in the drug class Antiviral Agents are used in the treatment of Coronavirus Disease 2019 (COVID-19)?

Antiviral Agents

Remdesivir (Veklury)

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