What severe reactions have been reported in patients undergoing chimeric antigen receptor (CAR) T-cell therapy?

Updated: May 04, 2018
  • Author: Sameh Gaballa, MD, MS; Chief Editor: Emmanuel C Besa, MD  more...
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Answer

Answer

Severe allergic reactions to CAR T cells have been reported. A patient with pleural mesothelioma developed severe anaphylaxis and cardiac arrest after his third infusion of CAR T-cell therapy. He required cardiopulmonary resuscitation but fortunately recovered. [28]  Additionally, tumor lysis syndrome has been reported in patients with ALL receiving CAR T-cell therapy. [25]


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